1vge

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[[Image:1vge.gif|left|200px]]
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{{Seed}}
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[[Image:1vge.png|left|200px]]
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{{STRUCTURE_1vge| PDB=1vge | SCENE= }}
{{STRUCTURE_1vge| PDB=1vge | SCENE= }}
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'''TR1.9 FAB FRAGMENT OF A HUMAN IGG1 KAPPA AUTOANTIBODY'''
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===TR1.9 FAB FRAGMENT OF A HUMAN IGG1 KAPPA AUTOANTIBODY===
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==Overview==
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The three-dimensional structure of the Fab of TR1.9, a high-affinity IgG1, kappa human autoantibody to thyroid peroxidase, was determined crystallographically to a resolution of 2.0 A. The combining site was found to be relatively flat, like other antibodies to large proteins. Sequence differences from the most closely related germline genes mainly occur at positions occupied by residues with outward-pointing side chains. An increased deformability of the second and third complementarity-determining regions of the heavy chain may result from the replacement of two germline asparagines and the presence of several glycines, and may allow "induced fit" in the binding to antigen. Four exposed charged residues, resulting from the use of a particular D (diversity) and J (joining) segments in the assembly of the heavy chain, may contribute to the high affinity of antigen binding. The crystal structure of TR1.9 Fab is the first for a human IgG high-affinity autoantibody.
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The line below this paragraph, {{ABSTRACT_PUBMED_8647813}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 8647813 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8647813}}
==About this Structure==
==About this Structure==
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[[Category: Immunoglobulin]]
[[Category: Immunoglobulin]]
[[Category: Tr1 9]]
[[Category: Tr1 9]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:30:39 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:24:49 2008''

Revision as of 13:24, 27 July 2008

Image:1vge.png

Template:STRUCTURE 1vge

TR1.9 FAB FRAGMENT OF A HUMAN IGG1 KAPPA AUTOANTIBODY

Template:ABSTRACT PUBMED 8647813

About this Structure

1VGE is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural studies of human autoantibodies. Crystal structure of a thyroid peroxidase autoantibody Fab., Chacko S, Padlan EA, Portolano S, McLachlan SM, Rapoport B, J Biol Chem. 1996 May 24;271(21):12191-8. PMID:8647813

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