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2fbo

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[[Image:2fbo.gif|left|200px]]
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{{STRUCTURE_2fbo| PDB=2fbo | SCENE= }}
{{STRUCTURE_2fbo| PDB=2fbo | SCENE= }}
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'''Crystal Structure of the Two Tandem V-type Regions of VCBP3 (v-region-containing chitin binding protein) to 1.85 A'''
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===Crystal Structure of the Two Tandem V-type Regions of VCBP3 (v-region-containing chitin binding protein) to 1.85 A===
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==Overview==
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Although the origins of genes encoding the rearranging binding receptors remain obscure, it is predicted that their ancestral forms were nonrearranging immunoglobulin-type domains. Variable region-containing chitin-binding proteins (VCBPs) are diversified immune-type molecules found in amphioxus (Branchiostoma floridae), an invertebrate that diverged early in deuterostome phylogeny. To study the potential evolutionary relationships between VCBPs and vertebrate adaptive immune receptors, we solved the structures of both a single V-type domain (to 1.15 A) and a pair of V-type domains (to 1.85 A) from VCBP3. The deduced structures show integral features of the ancestral variable-region fold as well as unique features of variable-region pairing in molecules that may reflect characteristics of ancestral forms of diversified immune receptors found in modern-day vertebrates.
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(as it appears on PubMed at http://www.pubmed.gov), where 16799561 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16799561}}
==About this Structure==
==About this Structure==
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[[Category: V-type]]
[[Category: V-type]]
[[Category: Vcbp]]
[[Category: Vcbp]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:41:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:38:14 2008''

Revision as of 13:38, 27 July 2008

Image:2fbo.png

Template:STRUCTURE 2fbo

Crystal Structure of the Two Tandem V-type Regions of VCBP3 (v-region-containing chitin binding protein) to 1.85 A

Template:ABSTRACT PUBMED 16799561

About this Structure

2FBO is a Single protein structure of sequence from Branchiostoma floridae. Full crystallographic information is available from OCA.

Reference

Ancient evolutionary origin of diversified variable regions demonstrated by crystal structures of an immune-type receptor in amphioxus., Hernandez Prada JA, Haire RN, Allaire M, Jakoncic J, Stojanoff V, Cannon JP, Litman GW, Ostrov DA, Nat Immunol. 2006 Aug;7(8):875-82. Epub 2006 Jun 25. PMID:16799561

Page seeded by OCA on Sun Jul 27 16:38:14 2008

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