2e4z

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{{STRUCTURE_2e4z| PDB=2e4z | SCENE= }}
{{STRUCTURE_2e4z| PDB=2e4z | SCENE= }}
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'''Crystal structure of the ligand-binding region of the group III metabotropic glutamate receptor'''
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===Crystal structure of the ligand-binding region of the group III metabotropic glutamate receptor===
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==Overview==
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Metabotropic glutamate receptors play major roles in the activation of excitatory synapses in the central nerve system. We determined the crystal structure of the entire extracellular region of the group II receptor and that of the ligand-binding region of the group III receptor. A comparison among groups I, II, and III provides the structural basis that could account for the discrimination of group-specific agonists. Furthermore, the structure of group II includes the cysteine-rich domain, which is tightly linked to the ligand-binding domain by a disulfide bridge, suggesting a potential role in transmitting a ligand-induced conformational change into the downstream transmembrane region. The structure also reveals the lateral interaction between the two cysteine-rich domains, which could stimulate clustering of the dimeric receptors on the cell surface. We propose a general activation mechanism of the dimeric receptor coupled with both ligand-binding and interprotomer rearrangements.
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The line below this paragraph, {{ABSTRACT_PUBMED_17360426}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17360426 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17360426}}
==About this Structure==
==About this Structure==
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[[Category: G-protein-coupled receptor]]
[[Category: G-protein-coupled receptor]]
[[Category: Neuron]]
[[Category: Neuron]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 01:55:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:48:42 2008''

Revision as of 13:48, 27 July 2008

Image:2e4z.png

Template:STRUCTURE 2e4z

Crystal structure of the ligand-binding region of the group III metabotropic glutamate receptor

Template:ABSTRACT PUBMED 17360426

About this Structure

2E4Z is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Structures of the extracellular regions of the group II/III metabotropic glutamate receptors., Muto T, Tsuchiya D, Morikawa K, Jingami H, Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):3759-64. Epub 2007 Feb 26. PMID:17360426

Page seeded by OCA on Sun Jul 27 16:48:42 2008

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