1vex

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{{STRUCTURE_1vex| PDB=1vex | SCENE= }}
{{STRUCTURE_1vex| PDB=1vex | SCENE= }}
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'''F-spondin TSR domain 4'''
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===F-spondin TSR domain 4===
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==Overview==
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F-spondin is a protein mainly associated with neuronal development. It attaches to the extracellular matrix and acts in the axon guidance of the developing nervous system. F-spondin consists of eight domains, six of which are TSR domains. The TSR domain family binds a wide range of targets. Here we present the NMR solution structures of TSR1 and TSR4. TSR domains have an unusual fold that is characterized by a long, nonglobular shape, consisting of two beta-strands and one irregular extended strand. Three disulfide bridges and stack of alternating tryptophan and arginine side-chains stabilize the structure. TSR1 and TSR4 structures are similar to each other and to the previously determined TSR domain X-ray structures from another protein, TSP, although TSR4 exhibits a mobile loop not seen in other structures.
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{{ABSTRACT_PUBMED_16736493}}
==About this Structure==
==About this Structure==
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1VEX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VEX OCA].
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1VEX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VEX OCA].
==Reference==
==Reference==
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[[Category: F-spondin]]
[[Category: F-spondin]]
[[Category: Tsr]]
[[Category: Tsr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:27:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:54:35 2008''

Revision as of 13:54, 27 July 2008

Image:1vex.png

Template:STRUCTURE 1vex

F-spondin TSR domain 4

Template:ABSTRACT PUBMED 16736493

About this Structure

1VEX is a Single protein structure of sequence from Rattus norvegicus. Full experimental information is available from OCA.

Reference

Solution structures of the first and fourth TSR domains of F-spondin., Paakkonen K, Tossavainen H, Permi P, Rakkolainen H, Rauvala H, Raulo E, Kilpelainen I, Guntert P, Proteins. 2006 Aug 15;64(3):665-72. PMID:16736493

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