2fa1

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{{STRUCTURE_2fa1| PDB=2fa1 | SCENE= }}
{{STRUCTURE_2fa1| PDB=2fa1 | SCENE= }}
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'''Crystal structure of PhnF C-terminal domain'''
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===Crystal structure of PhnF C-terminal domain===
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==Overview==
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The crystal structure of Escherichia coli PhnF C-terminal domain (C-PhnF) was solved at 1.7 A resolution by the single wavelength anomalous dispersion (SAD) method. The PhnF protein belongs to the HutC subfamily of the large GntR transcriptional regulator family. Members of this family share similar N-terminal DNA-binding domains, but are divided into four subfamilies according to their heterogenic C-terminal domains, which are involved in effector binding and oligomerization. The C-PhnF structure provides for the first time the scaffold of this domain for the HutC subfamily, which covers about 31% of GntR-like regulators. The structure represents a mixture of alpha-helices and beta-strands, with a six-stranded antiparallel beta-sheet at the core. C-PhnF monomers form a dimer by establishing interdomain eight-strand beta-sheets that include core antiparallel and N-terminal two-strand parallel beta-sheets from each monomer. C-PhnF shares strong structural similarity with the chorismate lyase fold, which features a buried active site locked behind two helix-turn-helix loops. The structural comparison of the C-PhnF and UbiC proteins allows us to propose that a similar site in the PhnF structure is adapted for effector binding.
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(as it appears on PubMed at http://www.pubmed.gov), where 16672238 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16672238}}
==About this Structure==
==About this Structure==
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[[Category: Regulator]]
[[Category: Regulator]]
[[Category: Transcription]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:38:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:55:06 2008''

Revision as of 13:55, 27 July 2008

Image:2fa1.png

Template:STRUCTURE 2fa1

Crystal structure of PhnF C-terminal domain

Template:ABSTRACT PUBMED 16672238

About this Structure

2FA1 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structural characterization of GntR/HutC family signaling domain., Gorelik M, Lunin VV, Skarina T, Savchenko A, Protein Sci. 2006 Jun;15(6):1506-11. Epub 2006 May 2. PMID:16672238

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