1tkn

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{{STRUCTURE_1tkn| PDB=1tkn | SCENE= }}
{{STRUCTURE_1tkn| PDB=1tkn | SCENE= }}
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'''Solution structure of CAPPD*, an independently folded extracellular domain of human Amyloid-beta Precursor Protein'''
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===Solution structure of CAPPD*, an independently folded extracellular domain of human Amyloid-beta Precursor Protein===
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==Overview==
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Cleavage of amyloid-beta precursor protein (APP) by site-specific proteases generates amyloid-beta peptides (Abetas), which are thought to induce Alzheimer's disease. We have identified an independently folded extracellular domain of human APP localized proximal to the Abeta sequence, and determined the three-dimensional structure of this domain by NMR spectroscopy. The domain is composed of four alpha-helices, three of which form a tight antiparallel bundle, and constitutes the C-terminal half of the central extracellular region of APP that has been implicated in the regulation of APP cleavage. Sequence comparisons demonstrate that the domain is highly conserved among all members of the APP family, including invertebrate homologues, suggesting an important role for this region in the biological function of APP. The identification of this domain and the availability of its atomic structure will facilitate analysis of APP function and of the role of the extracellular region in the regulation of APP cleavage.
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{{ABSTRACT_PUBMED_15274612}}
==About this Structure==
==About this Structure==
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1TKN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TKN OCA].
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1TKN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TKN OCA].
==Reference==
==Reference==
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[[Category: Four alpha-helice]]
[[Category: Four alpha-helice]]
[[Category: Three-helical bundle]]
[[Category: Three-helical bundle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:04:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:56:19 2008''

Revision as of 13:56, 27 July 2008

Image:1tkn.png

Template:STRUCTURE 1tkn

Solution structure of CAPPD*, an independently folded extracellular domain of human Amyloid-beta Precursor Protein

Template:ABSTRACT PUBMED 15274612

About this Structure

1TKN is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Three-dimensional structure of an independently folded extracellular domain of human amyloid-beta precursor protein., Dulubova I, Ho A, Huryeva I, Sudhof TC, Rizo J, Biochemistry. 2004 Aug 3;43(30):9583-8. PMID:15274612

Page seeded by OCA on Sun Jul 27 16:56:19 2008

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