1vfp

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{{STRUCTURE_1vfp| PDB=1vfp | SCENE= }}
{{STRUCTURE_1vfp| PDB=1vfp | SCENE= }}
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'''Crystal structure of the SR CA2+-ATPase with bound AMPPCP'''
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===Crystal structure of the SR CA2+-ATPase with bound AMPPCP===
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==Overview==
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P-type ATPases are ATP-powered ion pumps that establish ion concentration gradients across cell and organelle membranes. Here, we describe the crystal structure of the Ca2+ pump of skeletal muscle sarcoplasmic reticulum, a representative member of the P-type ATPase superfamily, with an ATP analogue, a Mg2+ and two Ca2+ ions in the respective binding sites. In this state, the ATP analogue reorganizes the three cytoplasmic domains (A, N and P), which are widely separated without nucleotide, by directly bridging the N and P domains. The structure of the P-domain itself is altered by the binding of the ATP analogue and Mg2+. As a result, the A-domain is tilted so that one of the transmembrane helices moves to lock the cytoplasmic gate of the transmembrane Ca2+-binding sites. This appears to be the mechanism for occluding the bound Ca2+ ions, before releasing them into the lumen of the sarcoplasmic reticulum.
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The line below this paragraph, {{ABSTRACT_PUBMED_15229613}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15229613 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15229613}}
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
Crystal structure of the calcium pump with a bound ATP analogue., Toyoshima C, Mizutani T, Nature. 2004 Jul 29;430(6999):529-35. Epub 2004 Jun 30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15229613 15229613]
Crystal structure of the calcium pump with a bound ATP analogue., Toyoshima C, Mizutani T, Nature. 2004 Jul 29;430(6999):529-35. Epub 2004 Jun 30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15229613 15229613]
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Structural biology. Pumping ions., MacLennan DH, Green NM, Nature. 2000 Jun 8;405(6787):633-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10864310 10864310]
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Calcium callisthenics., Green NM, MacLennan DH, Nature. 2002 Aug 8;418(6898):598-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12167844 12167844]
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Structural basis of ion pumping by Ca(2+)-ATPase of sarcoplasmic reticulum., Toyoshima C, Nomura H, Sugita Y, FEBS Lett. 2003 Nov 27;555(1):106-10. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14630328 14630328]
[[Category: Calcium-transporting ATPase]]
[[Category: Calcium-transporting ATPase]]
[[Category: Oryctolagus cuniculus]]
[[Category: Oryctolagus cuniculus]]
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[[Category: Membrane protein]]
[[Category: Membrane protein]]
[[Category: P-type atpase]]
[[Category: P-type atpase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:29:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:00:10 2008''

Revision as of 14:00, 27 July 2008

Image:1vfp.png

Template:STRUCTURE 1vfp

Crystal structure of the SR CA2+-ATPase with bound AMPPCP

Template:ABSTRACT PUBMED 15229613

About this Structure

1VFP is a Single protein structure of sequence from Oryctolagus cuniculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the calcium pump with a bound ATP analogue., Toyoshima C, Mizutani T, Nature. 2004 Jul 29;430(6999):529-35. Epub 2004 Jun 30. PMID:15229613

Structural biology. Pumping ions., MacLennan DH, Green NM, Nature. 2000 Jun 8;405(6787):633-4. PMID:10864310

Calcium callisthenics., Green NM, MacLennan DH, Nature. 2002 Aug 8;418(6898):598-9. PMID:12167844

Structural basis of ion pumping by Ca(2+)-ATPase of sarcoplasmic reticulum., Toyoshima C, Nomura H, Sugita Y, FEBS Lett. 2003 Nov 27;555(1):106-10. PMID:14630328

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