This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2uw0

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2uw0.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2uw0.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2uw0| PDB=2uw0 | SCENE= }}
{{STRUCTURE_2uw0| PDB=2uw0 | SCENE= }}
-
'''STRUCTURE OF PKA-PKB CHIMERA COMPLEXED WITH 6-(4-(4-(4-CHLORO-PHENYL)-PIPERIDIN-4-YL)-PHENYL)-9H-PURINE'''
+
===STRUCTURE OF PKA-PKB CHIMERA COMPLEXED WITH 6-(4-(4-(4-CHLORO-PHENYL)-PIPERIDIN-4-YL)-PHENYL)-9H-PURINE===
-
==Overview==
+
<!--
-
6-phenylpurines were identified as novel, ATP-competitive inhibitors of protein kinase B (PKB/Akt) from a fragment-based screen and were rapidly progressed to potent compounds using iterative protein-ligand crystallography with a PKA-PKB chimeric protein. An elaborated lead compound showed cell growth inhibition and effects on cellular signaling pathways characteristic of PKB inhibition.
+
The line below this paragraph, {{ABSTRACT_PUBMED_17451235}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 17451235 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_17451235}}
==About this Structure==
==About this Structure==
Line 43: Line 47:
[[Category: Transferase]]
[[Category: Transferase]]
[[Category: Transferase/inhibitor complex]]
[[Category: Transferase/inhibitor complex]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 17:37:18 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:03:37 2008''

Revision as of 14:03, 27 July 2008

Image:2uw0.png

Template:STRUCTURE 2uw0

STRUCTURE OF PKA-PKB CHIMERA COMPLEXED WITH 6-(4-(4-(4-CHLORO-PHENYL)-PIPERIDIN-4-YL)-PHENYL)-9H-PURINE

Template:ABSTRACT PUBMED 17451235

About this Structure

2UW0 is a Protein complex structure of sequences from Bos taurus. Full crystallographic information is available from OCA.

Reference

Rapid evolution of 6-phenylpurine inhibitors of protein kinase B through structure-based design., Donald A, McHardy T, Rowlands MG, Hunter LJ, Davies TG, Berdini V, Boyle RG, Aherne GW, Garrett MD, Collins I, J Med Chem. 2007 May 17;50(10):2289-92. Epub 2007 Apr 24. PMID:17451235

Page seeded by OCA on Sun Jul 27 17:03:37 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2uw0"
Personal tools