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| | {{STRUCTURE_1wip| PDB=1wip | SCENE= }} | | {{STRUCTURE_1wip| PDB=1wip | SCENE= }} |
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| - | '''STRUCTURE OF T-CELL SURFACE GLYCOPROTEIN CD4, MONOCLINIC CRYSTAL FORM'''
| + | ===STRUCTURE OF T-CELL SURFACE GLYCOPROTEIN CD4, MONOCLINIC CRYSTAL FORM=== |
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| - | ==Overview==
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| - | CD4 is a co-receptor in the cellular immune response. It increases the avidity of association between a T cell and an antigen-presenting cell by interacting with non-polymorphic portions of the complex between class II major histocompatibility complex (MHC) and T-cell receptor (TCR) molecules, and it contributes directly to signal transduction through its cytoplasmic association with the lymphocyte kinase Lck. CD4 also serves as the high-affinity receptor for cellular attachment and entry of the human immunodeficiency virus (HIV). The extracellular portion of CD4 comprises four immunoglobulin-like domains (D1-D4). This part of human CD4 (residues 1-369) has been characterized as a recombinant soluble protein (sCD4), and crystal structures have been described for the human D1D2 fragment and for the rat D3D4 fragment. We have now determined the structures of intact sCD4 in three crystal lattices. These structures have a hinge-like variability at the D1D2 to D3D4 junction that might be important in immune recognition and HIV fusion, and a common dimeric association through D4 domains. Dynamic light scattering measurements and chemical crosslinking of sCD4 corroborate dimerization at high protein concentration. We suggest that such dimers mayhave relevance as mediators of signal transduction in T cells.
| + | The line below this paragraph, {{ABSTRACT_PUBMED_9168119}}, adds the Publication Abstract to the page |
| | + | (as it appears on PubMed at http://www.pubmed.gov), where 9168119 is the PubMed ID number. |
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| | + | {{ABSTRACT_PUBMED_9168119}} |
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| | ==About this Structure== | | ==About this Structure== |
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| | [[Category: T-cell]] | | [[Category: T-cell]] |
| | [[Category: Transmembrane]] | | [[Category: Transmembrane]] |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:44:11 2008'' | + | |
| | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:33:55 2008'' |
Revision as of 14:33, 27 July 2008
Template:STRUCTURE 1wip
STRUCTURE OF T-CELL SURFACE GLYCOPROTEIN CD4, MONOCLINIC CRYSTAL FORM
Template:ABSTRACT PUBMED 9168119
About this Structure
1WIP is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Dimeric association and segmental variability in the structure of human CD4., Wu H, Kwong PD, Hendrickson WA, Nature. 1997 May 29;387(6632):527-30. PMID:9168119
Page seeded by OCA on Sun Jul 27 17:33:55 2008
