2nov

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{{STRUCTURE_2nov| PDB=2nov | SCENE= }}
{{STRUCTURE_2nov| PDB=2nov | SCENE= }}
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'''Breakage-reunion domain of S.pneumoniae topo IV: crystal structure of a gram-positive quinolone target'''
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===Breakage-reunion domain of S.pneumoniae topo IV: crystal structure of a gram-positive quinolone target===
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==Overview==
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The 2.7 A crystal structure of the 55-kDa N-terminal breakage-reunion domain of topoisomerase (topo) IV subunit A (ParC) from Streptococcus pneumoniae, the first for the quinolone targets from a gram-positive bacterium, has been solved and reveals a 'closed' dimer similar in fold to Escherichia coli DNA gyrase subunit A (GyrA), but distinct from the 'open' gate structure of Escherichia coli ParC. Unlike GyrA whose DNA binding groove is largely positively charged, the DNA binding site of ParC exhibits a distinct pattern of alternating positively and negatively charged regions coincident with the predicted positions of the grooves and phosphate backbone of DNA. Based on the ParC structure, a new induced-fit model for sequence-specific recognition of the gate (G) segment by ParC has been proposed. These features may account for the unique DNA recognition and quinolone targeting properties of pneumococcal type II topoisomerases compared to their gram-negative counterparts.
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(as it appears on PubMed at http://www.pubmed.gov), where 17375187 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17375187}}
==About this Structure==
==About this Structure==
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[[Category: Quinolone target]]
[[Category: Quinolone target]]
[[Category: Topo iv]]
[[Category: Topo iv]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:43:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:59:09 2008''

Revision as of 14:59, 27 July 2008

Image:2nov.png

Template:STRUCTURE 2nov

Breakage-reunion domain of S.pneumoniae topo IV: crystal structure of a gram-positive quinolone target

Template:ABSTRACT PUBMED 17375187

About this Structure

2NOV is a Single protein structure of sequence from Streptococcus pneumoniae. Full crystallographic information is available from OCA.

Reference

Breakage-reunion domain of Streptococcus pneumoniae topoisomerase IV: crystal structure of a gram-positive quinolone target., Laponogov I, Veselkov DA, Sohi MK, Pan XS, Achari A, Yang C, Ferrara JD, Fisher LM, Sanderson MR, PLoS ONE. 2007 Mar 21;2(3):e301. PMID:17375187

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