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1qx7

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{{STRUCTURE_1qx7| PDB=1qx7 | SCENE= }}
{{STRUCTURE_1qx7| PDB=1qx7 | SCENE= }}
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'''Crystal structure of apoCaM bound to the gating domain of small conductance Ca2+-activated potassium channel'''
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===Crystal structure of apoCaM bound to the gating domain of small conductance Ca2+-activated potassium channel===
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==Overview==
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Small conductance Ca2+-activated K+ channels (SK channels) are composed of the pore-forming alpha subunit and calmodulin (CaM). CaM binds to a region of the alpha subunit called the CaM binding domain (CaMBD), located intracellular and immediately C-terminal to the inner helix gate, in either the presence or absence of Ca2+. SK gating occurs when Ca2+ binds the N lobe of CaM thereby transmitting the signal to the attached inner helix gate to open. Here we present crystal structures of apoCaM and apoCaM/SK2 CaMBD complex. Several apoCaM crystal forms with multiple (12) packing environments reveal the same EF hand domain-swapped dimer providing potentially new insight into CaM regulation. The apoCaM/SK2 CaMBD structure, combined with our Ca2+/CaM/CaMBD structure suggests that Ca2+ binding induces folding and dimerization of the CaMBD, which causes large CaMBD-CaM C lobe conformational changes, including a &gt;90 degrees rotation of the region of the CaMBD directly connected to the gate.
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(as it appears on PubMed at http://www.pubmed.gov), where 15130477 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15130477}}
==About this Structure==
==About this Structure==
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[[Category: Sk channel]]
[[Category: Sk channel]]
[[Category: Small conductance ca2+ activated k+ channel]]
[[Category: Small conductance ca2+ activated k+ channel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:48:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:26:20 2008''

Revision as of 15:26, 27 July 2008

Image:1qx7.png

Template:STRUCTURE 1qx7

Crystal structure of apoCaM bound to the gating domain of small conductance Ca2+-activated potassium channel

Template:ABSTRACT PUBMED 15130477

About this Structure

1QX7 is a Protein complex structure of sequences from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Crystal structures of apocalmodulin and an apocalmodulin/SK potassium channel gating domain complex., Schumacher MA, Crum M, Miller MC, Structure. 2004 May;12(5):849-60. PMID:15130477

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