This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1wz9

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1wz9.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1wz9.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1wz9| PDB=1wz9 | SCENE= }}
{{STRUCTURE_1wz9| PDB=1wz9 | SCENE= }}
-
'''The 2.1 A structure of a tumour suppressing serpin'''
+
===The 2.1 A structure of a tumour suppressing serpin===
-
==Overview==
+
<!--
-
Maspin is a serpin that acts as a tumor suppressor in a range of human cancers, including tumors of the breast and lung. Maspin is crucial for development, because homozygous loss of the gene is lethal; however, the precise physiological role of the molecule is unclear. To gain insight into the function of human maspin, we have determined its crystal structure in two similar, but non-isomorphous crystal forms, to 2.1- and 2.8-A resolution, respectively. The structure reveals that maspin adopts the native serpin fold in which the reactive center loop is expelled fully from the A beta-sheet, makes minimal contacts with the core of the molecule, and exhibits a high degree of flexibility. A buried salt bridge unique to maspin orthologues causes an unusual bulge in the region around the D and E alpha-helices, an area of the molecule demonstrated in other serpins to be important for cofactor recognition. Strikingly, the structural data reveal that maspin is able to undergo conformational change in and around the G alpha-helix, switching between an open and a closed form. This change dictates the electrostatic character of a putative cofactor binding surface and highlights this region as a likely determinant of maspin function. The high resolution crystal structure of maspin provides a detailed molecular framework to elucidate the mechanism of function of this important tumor suppressor.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15760906}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15760906 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15760906}}
==About this Structure==
==About this Structure==
Line 39: Line 43:
[[Category: Serpinb5]]
[[Category: Serpinb5]]
[[Category: Tumor suppressor]]
[[Category: Tumor suppressor]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:20:27 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:32:05 2008''

Revision as of 15:32, 27 July 2008

Image:1wz9.png

Template:STRUCTURE 1wz9

The 2.1 A structure of a tumour suppressing serpin

Template:ABSTRACT PUBMED 15760906

About this Structure

1WZ9 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The high resolution crystal structure of the human tumor suppressor maspin reveals a novel conformational switch in the G-helix., Law RH, Irving JA, Buckle AM, Ruzyla K, Buzza M, Bashtannyk-Puhalovich TA, Beddoe TC, Nguyen K, Worrall DM, Bottomley SP, Bird PI, Rossjohn J, Whisstock JC, J Biol Chem. 2005 Jun 10;280(23):22356-64. Epub 2005 Mar 10. PMID:15760906

Page seeded by OCA on Sun Jul 27 18:32:05 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1wz9"
Personal tools