This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2awc

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2awc.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2awc.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2awc| PDB=2awc | SCENE= }}
{{STRUCTURE_2awc| PDB=2awc | SCENE= }}
-
'''deoxy-DcrH-Hr'''
+
===deoxy-DcrH-Hr===
-
==Overview==
+
<!--
-
The methyl-accepting chemotaxis protein, DcrH, from the anaerobic sulfate-reducing bacterium, Desulfovibrio vulgaris (Hildenborough), has a hemerythrin-like domain, DcrH-Hr, at its C terminus. DcrH-Hr was previously shown to contain a diiron site that binds O2, suggesting an O2-sensing function. X-ray crystal structures of diferric (met-), azido-diferric (azidomet-), and diferrous (deoxy-) DcrH-Hr reveal a "substrate tunnel" distinct from that in invertebrate hemerythrins. This tunnel is proposed to facilitate the rapid autoxidation of oxy-DcrH-Hr and suggests that sensing is triggered by O2 binding and subsequent oxidation of the diferrous active site. The N-terminal loop of DcrH-Hr is highly ordered in both met- and azidomet-DcrH-Hr but is disordered in deoxy-DcrH-Hr. These redox-dependent conformational differences presumably transduce the sensory signal of DcrH-Hr to the neighboring methylation domain in the full-length receptor. Given the putative cytoplasmic localization of its Hr-like O2-sensing domain, DcrH is proposed to serve a role in negative aerotaxis (anaerotaxis).
+
The line below this paragraph, {{ABSTRACT_PUBMED_16866347}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 16866347 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_16866347}}
==About this Structure==
==About this Structure==
Line 28: Line 32:
[[Category: Silaghi-Dumitrescu, R.]]
[[Category: Silaghi-Dumitrescu, R.]]
[[Category: Four helix bundle]]
[[Category: Four helix bundle]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:33:04 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:39:02 2008''

Revision as of 15:39, 27 July 2008

Image:2awc.png

Template:STRUCTURE 2awc

deoxy-DcrH-Hr

Template:ABSTRACT PUBMED 16866347

About this Structure

2AWC is a Single protein structure of sequence from Desulfovibrio vulgaris. Full crystallographic information is available from OCA.

Reference

Structural basis for O2 sensing by the hemerythrin-like domain of a bacterial chemotaxis protein: substrate tunnel and fluxional N terminus., Isaza CE, Silaghi-Dumitrescu R, Iyer RB, Kurtz DM Jr, Chan MK, Biochemistry. 2006 Aug 1;45(30):9023-31. PMID:16866347

Page seeded by OCA on Sun Jul 27 18:39:02 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2awc"
Personal tools