1or7

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[[Image:1or7.gif|left|200px]]
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{{STRUCTURE_1or7| PDB=1or7 | SCENE= }}
{{STRUCTURE_1or7| PDB=1or7 | SCENE= }}
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'''Crystal Structure of Escherichia coli sigmaE with the Cytoplasmic Domain of its Anti-sigma RseA'''
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===Crystal Structure of Escherichia coli sigmaE with the Cytoplasmic Domain of its Anti-sigma RseA===
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==Overview==
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The sigma factors are the key regulators of bacterial transcription. ECF (extracytoplasmic function) sigma's are the largest and most divergent group of sigma(70) family members. ECF sigma's are normally sequestered in an inactive complex by their specific anti-sigma factor, which often spans the inner membrane. Here, we determined the 2 A resolution crystal structure of the Escherichia coli ECF sigma factor sigma(E) in an inhibitory complex with the cytoplasmic domain of its anti-sigma, RseA. Despite extensive sequence variability, the two major domains of sigma(E) are virtually identical in structure to the corresponding domains of other sigma(70) family members. In combination with a model of the sigma(E) holoenzyme and biochemical data, the structure reveals that RseA functions by sterically occluding the two primary binding determinants on sigma(E) for core RNA polymerase.
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(as it appears on PubMed at http://www.pubmed.gov), where 12718891 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12718891}}
==About this Structure==
==About this Structure==
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[[Category: Regulation]]
[[Category: Regulation]]
[[Category: Transmembrane]]
[[Category: Transmembrane]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:11:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:54:41 2008''

Revision as of 15:54, 27 July 2008

Image:1or7.png

Template:STRUCTURE 1or7

Crystal Structure of Escherichia coli sigmaE with the Cytoplasmic Domain of its Anti-sigma RseA

Template:ABSTRACT PUBMED 12718891

About this Structure

1OR7 is a Protein complex structure of sequences from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of Escherichia coli sigmaE with the cytoplasmic domain of its anti-sigma RseA., Campbell EA, Tupy JL, Gruber TM, Wang S, Sharp MM, Gross CA, Darst SA, Mol Cell. 2003 Apr;11(4):1067-78. PMID:12718891

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