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2d3m

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[[Image:2d3m.gif|left|200px]]
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{{Seed}}
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[[Image:2d3m.png|left|200px]]
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{{STRUCTURE_2d3m| PDB=2d3m | SCENE= }}
{{STRUCTURE_2d3m| PDB=2d3m | SCENE= }}
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'''Pentaketide chromone synthase complexed with coenzyme A'''
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===Pentaketide chromone synthase complexed with coenzyme A===
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==Overview==
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The crystal structures of a wild-type and a mutant PCS, a novel plant type III polyketide synthase from a medicinal plant, Aloe arborescens, were solved at 1.6 A resolution. The crystal structures revealed that the pentaketide-producing wild-type and the octaketide-producing M207G mutant shared almost the same overall folding, and that the large-to-small substitution dramatically increases the volume of the polyketide-elongation tunnel by opening a gate to two hidden pockets behind the active site of the enzyme. The chemically inert active site residue 207 thus controls the number of condensations of malonyl-CoA, solely depending on the steric bulk of the side chain. These findings not only provided insight into the polyketide formation reaction, but they also suggested strategies for the engineered biosynthesis of polyketides.
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(as it appears on PubMed at http://www.pubmed.gov), where 17462571 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17462571}}
==About this Structure==
==About this Structure==
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[[Category: Pentaketide chromone synthase]]
[[Category: Pentaketide chromone synthase]]
[[Category: Polyketide synthase]]
[[Category: Polyketide synthase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 23:38:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:06:18 2008''

Revision as of 16:06, 27 July 2008

Image:2d3m.png

Template:STRUCTURE 2d3m

Pentaketide chromone synthase complexed with coenzyme A

Template:ABSTRACT PUBMED 17462571

About this Structure

2D3M is a Single protein structure of sequence from Aloe arborescens. Full crystallographic information is available from OCA.

Reference

Structural insight into chain-length control and product specificity of pentaketide chromone synthase from Aloe arborescens., Morita H, Kondo S, Oguro S, Noguchi H, Sugio S, Abe I, Kohno T, Chem Biol. 2007 Apr;14(4):359-69. PMID:17462571

Page seeded by OCA on Sun Jul 27 19:06:18 2008

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