1nez

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[[Image:1nez.jpg|left|200px]]
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{{STRUCTURE_1nez| PDB=1nez | SCENE= }}
{{STRUCTURE_1nez| PDB=1nez | SCENE= }}
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'''The Crystal Structure of a TL/CD8aa Complex at 2.1A resolution:Implications for Memory T cell Generation, Co-receptor Preference and Affinity'''
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===The Crystal Structure of a TL/CD8aa Complex at 2.1A resolution:Implications for Memory T cell Generation, Co-receptor Preference and Affinity===
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==Overview==
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TL is a nonclassical MHC class I molecule that modulates T cell activation through relatively high-affinity interaction with CD8alphaalpha. To investigate how the TL/CD8alphaalpha interaction influences TCR signaling, we characterized the structure of the TL/CD8alphaalpha complex using X-ray crystallography. Unlike antigen-presenting molecules, the TL antigen-binding groove is occluded by specific conformational changes. This feature eliminates antigen presentation, severely hampers direct TCR recognition, and prevents TL from participating in the TCR activation complex. At the same time, the TL/CD8alphaalpha interaction is strengthened through subtle structure changes in the TL alpha3 domain. Thus, TL functions to sequester and redirect CD8alphaalpha away from the TCR, modifying lck-dependent signaling.
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The line below this paragraph, {{ABSTRACT_PUBMED_12594948}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12594948 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12594948}}
==About this Structure==
==About this Structure==
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[[Category: Zhang, R.]]
[[Category: Zhang, R.]]
[[Category: Immune system]]
[[Category: Immune system]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:27:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:13:04 2008''

Revision as of 16:13, 27 July 2008

Image:1nez.png

Template:STRUCTURE 1nez

The Crystal Structure of a TL/CD8aa Complex at 2.1A resolution:Implications for Memory T cell Generation, Co-receptor Preference and Affinity

Template:ABSTRACT PUBMED 12594948

About this Structure

1NEZ is a Protein complex structure. Full crystallographic information is available from OCA.

Reference

The crystal structure of a TL/CD8alphaalpha complex at 2.1 A resolution: implications for modulation of T cell activation and memory., Liu Y, Xiong Y, Naidenko OV, Liu JH, Zhang R, Joachimiak A, Kronenberg M, Cheroutre H, Reinherz EL, Wang JH, Immunity. 2003 Feb;18(2):205-15. PMID:12594948

Page seeded by OCA on Sun Jul 27 19:13:04 2008

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