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2q5k

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[[Image:2q5k.gif|left|200px]]
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{{STRUCTURE_2q5k| PDB=2q5k | SCENE= }}
{{STRUCTURE_2q5k| PDB=2q5k | SCENE= }}
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'''Crystal structure of lopinavir bound to wild type HIV-1 protease'''
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===Crystal structure of lopinavir bound to wild type HIV-1 protease===
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==Overview==
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A series of novel HIV-1 protease inhibitors based on two pseudosymmetric dipeptide isosteres have been synthesized and evaluated. The inhibitors were designed by incorporating N-phenyloxazolidinone-5-carboxamides into the hydroxyethylene and (hydroxyethyl)hydrazine dipeptide isosteres as P2 and P2' ligands. Compounds with (S)-phenyloxazolidinones attached at a position proximal to the central hydroxyl group showed low nM inhibitory activities against wild-type HIV-1 protease. Selected compounds were further evaluated for their inhibitory activities against a panel of multidrug-resistant protease variants and for their antiviral potencies in MT-4 cells. The crystal structures of lopinavir (LPV) and two new inhibitors containing phenyloxazolidinone-based ligands in complex with wild-type HIV-1 protease have been determined. A comparison of the inhibitor-protease structures with the LPV-protease structure provides valuable insight into the binding mode of the new inhibitors to the protease enzyme. Based on the crystal structures and knowledge of structure-activity relationships, new inhibitors can be designed with enhanced enzyme inhibitory and antiviral potencies.
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(as it appears on PubMed at http://www.pubmed.gov), where 17696512 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17696512}}
==About this Structure==
==About this Structure==
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[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: Protease inhibitor]]
[[Category: Protease inhibitor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 14:23:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:43:11 2008''

Revision as of 16:43, 27 July 2008

Image:2q5k.png

Template:STRUCTURE 2q5k

Crystal structure of lopinavir bound to wild type HIV-1 protease

Template:ABSTRACT PUBMED 17696512

About this Structure

2Q5K is a Single protein structure of sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

Design and synthesis of HIV-1 protease inhibitors incorporating oxazolidinones as P2/P2' ligands in pseudosymmetric dipeptide isosteres., Reddy GS, Ali A, Nalam MN, Anjum SG, Cao H, Nathans RS, Schiffer CA, Rana TM, J Med Chem. 2007 Sep 6;50(18):4316-28. Epub 2007 Aug 16. PMID:17696512

Page seeded by OCA on Sun Jul 27 19:43:11 2008

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