3aig

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{{STRUCTURE_3aig| PDB=3aig | SCENE= }}
{{STRUCTURE_3aig| PDB=3aig | SCENE= }}
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'''ADAMALYSIN II WITH PEPTIDOMIMETIC INHIBITOR POL656'''
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===ADAMALYSIN II WITH PEPTIDOMIMETIC INHIBITOR POL656===
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==Overview==
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Crotalus adamanteus snake venom adamalysin II is the structural prototype of the adamalysin or ADAM family comprising proteolytic domains of snake venom metalloproteinases, multimodular mammalian reproductive tract proteins, and tumor necrosis factor alpha convertase, TACE, involved in the release of the inflammatory cytokine, TNFalpha. The structure of adamalysin II in noncovalent complex with two small-molecule right-hand side peptidomimetic inhibitors (Pol 647 and Pol 656) has been solved using X-ray diffraction data up to 2.6 and 2.8 A resolution. The inhibitors bind to the S'-side of the proteinase, inserting between two protein segments, establishing a mixed parallel-antiparallel three-stranded beta-sheet and coordinate the central zinc ion in a bidentate manner via their two C-terminal oxygen atoms. The proteinase-inhibitor complexes are described in detail and are compared with other known structures. An adamalysin-based model of the active site of TACE reveals that these small molecules would probably fit into the active site cleft of this latter metalloproteinase, providing a starting model for the rational design of TACE inhibitors.
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{{ABSTRACT_PUBMED_9521103}}
==About this Structure==
==About this Structure==
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[[Category: Snake venom metalloendopetidase]]
[[Category: Snake venom metalloendopetidase]]
[[Category: Zinc protease]]
[[Category: Zinc protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:19:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:00:01 2008''

Revision as of 17:00, 27 July 2008

Image:3aig.png

Template:STRUCTURE 3aig

ADAMALYSIN II WITH PEPTIDOMIMETIC INHIBITOR POL656

Template:ABSTRACT PUBMED 9521103

About this Structure

3AIG is a Single protein structure of sequence from Crotalus adamanteus. Full crystallographic information is available from OCA.

Reference

Structures of adamalysin II with peptidic inhibitors. Implications for the design of tumor necrosis factor alpha convertase inhibitors., Gomis-Ruth FX, Meyer EF, Kress LF, Politi V, Protein Sci. 1998 Feb;7(2):283-92. PMID:9521103

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