2f90

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{{STRUCTURE_2f90| PDB=2f90 | SCENE= }}
{{STRUCTURE_2f90| PDB=2f90 | SCENE= }}
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'''Crystal structure of bisphosphoglycerate mutase in complex with 3-phosphoglycerate and AlF4-'''
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===Crystal structure of bisphosphoglycerate mutase in complex with 3-phosphoglycerate and AlF4-===
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==Overview==
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Bisphosphoglycerate mutase is an erythrocyte-specific enzyme catalyzing a series of intermolecular phosphoryl group transfer reactions. Its main function is to synthesize 2,3-bisphosphoglycerate, the allosteric effector of hemoglobin. In this paper, we directly observed real-time motion of the enzyme active site and the substrate during phosphoryl transfer. A series of high resolution crystal structures of human bisphosphoglycerate mutase co-crystallized with 2,3-bisphosphoglycerate, representing different time points in the phosphoryl transfer reaction, were solved. These structures not only clarify the argument concerning the substrate binding mode for this enzyme family but also depict the entire process of the key histidine phosphorylation as a "slow movie". It was observed that the enzyme conformation continuously changed during the different states of the reaction. These results provide direct evidence for an "in line" phosphoryl transfer mechanism, and the roles of some key residues in the phosphoryl transfer process are identified.
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The line below this paragraph, {{ABSTRACT_PUBMED_17052986}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17052986 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17052986}}
==About this Structure==
==About this Structure==
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[[Category: Wei, Z.]]
[[Category: Wei, Z.]]
[[Category: Bisphosphoglycerate mutase]]
[[Category: Bisphosphoglycerate mutase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:36:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:08:23 2008''

Revision as of 17:08, 27 July 2008

Image:2f90.png

Template:STRUCTURE 2f90

Crystal structure of bisphosphoglycerate mutase in complex with 3-phosphoglycerate and AlF4-

Template:ABSTRACT PUBMED 17052986

About this Structure

2F90 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Seeing the process of histidine phosphorylation in human bisphosphoglycerate mutase., Wang Y, Liu L, Wei Z, Cheng Z, Lin Y, Gong W, J Biol Chem. 2006 Dec 22;281(51):39642-8. Epub 2006 Oct 18. PMID:17052986

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