1yuw

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1yuw.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1yuw.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1yuw| PDB=1yuw | SCENE= }}
{{STRUCTURE_1yuw| PDB=1yuw | SCENE= }}
-
'''crystal structure of bovine hsc70(aa1-554)E213A/D214A mutant'''
+
===crystal structure of bovine hsc70(aa1-554)E213A/D214A mutant===
-
==Overview==
+
<!--
-
Hsp70 family proteins are highly conserved chaperones involved in protein folding, degradation, targeting and translocation, and protein complex remodeling. They are comprised of an N-terminal nucleotide binding domain (NBD) and a C-terminal protein substrate binding domain (SBD). ATP binding to the NBD alters SBD conformation and substrate binding kinetics, but an understanding of the mechanism of interdomain communication has been hampered by the lack of a crystal structure of an intact chaperone. We report here the 2.6 angstroms structure of a functionally intact bovine Hsc70 (bHsc70) and a mutational analysis of the observed interdomain interface and the immediately adjacent interdomain linker. This analysis identifies interdomain interactions critical for chaperone function and supports an allosteric mechanism in which the interdomain linker invades and disrupts the interdomain interface when ATP binds.
+
The line below this paragraph, {{ABSTRACT_PUBMED_16307916}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 16307916 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_16307916}}
==About this Structure==
==About this Structure==
Line 27: Line 31:
[[Category: Sousa, R.]]
[[Category: Sousa, R.]]
[[Category: Chaperone]]
[[Category: Chaperone]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:49:05 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:12:55 2008''

Revision as of 17:12, 27 July 2008

Image:1yuw.png

Template:STRUCTURE 1yuw

crystal structure of bovine hsc70(aa1-554)E213A/D214A mutant

Template:ABSTRACT PUBMED 16307916

About this Structure

1YUW is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Structural basis of interdomain communication in the Hsc70 chaperone., Jiang J, Prasad K, Lafer EM, Sousa R, Mol Cell. 2005 Nov 23;20(4):513-24. PMID:16307916

Page seeded by OCA on Sun Jul 27 20:12:55 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1yuw"
Personal tools