1zaf

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[[Image:1zaf.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1zaf| PDB=1zaf | SCENE= }}
{{STRUCTURE_1zaf| PDB=1zaf | SCENE= }}
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'''Crystal structure of estrogen receptor beta complexed with 3-Bromo-6-hydroxy-2-(4-hydroxy-phenyl)-inden-1-one'''
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===Crystal structure of estrogen receptor beta complexed with 3-Bromo-6-hydroxy-2-(4-hydroxy-phenyl)-inden-1-one===
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==Overview==
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The syntheses of a series of 2-arylindene-1-ones as potent ligands of ERbeta and ERalpha are described. Several compounds exhibited high potency and moderate selectivity for the ERbeta receptor. X-ray and modeling studies were used to understand ligand binding orientation and observed affinity.
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The line below this paragraph, {{ABSTRACT_PUBMED_15876535}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15876535 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15876535}}
==About this Structure==
==About this Structure==
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[[Category: Nuclear receptor]]
[[Category: Nuclear receptor]]
[[Category: Transcription factor]]
[[Category: Transcription factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:23:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:18:50 2008''

Revision as of 17:18, 27 July 2008

Template:STRUCTURE 1zaf

Crystal structure of estrogen receptor beta complexed with 3-Bromo-6-hydroxy-2-(4-hydroxy-phenyl)-inden-1-one

Template:ABSTRACT PUBMED 15876535

About this Structure

1ZAF is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Estrogen receptor ligands: design and synthesis of new 2-arylindene-1-ones., McDevitt RE, Malamas MS, Manas ES, Unwalla RJ, Xu ZB, Miller CP, Harris HA, Bioorg Med Chem Lett. 2005 Jun 15;15(12):3137-42. PMID:15876535

Page seeded by OCA on Sun Jul 27 20:18:50 2008

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