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1q8k

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[[Image:1q8k.gif|left|200px]]
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{{STRUCTURE_1q8k| PDB=1q8k | SCENE= }}
{{STRUCTURE_1q8k| PDB=1q8k | SCENE= }}
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'''Solution structure of alpha subunit of human eIF2'''
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===Solution structure of alpha subunit of human eIF2===
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==Overview==
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The GTP-bound form of the trimeric eukaryotic translation initiation factor 2 (eIF2) transfers aminoacylated initiator methionyl tRNA onto the 40S ribosome. We have solved with solution NMR the structure of the alpha subunit of human eIF2 (heIF2alpha). The protein consists of two domains that are mobile relative to each other. The N-terminal domain has an S1-type oligonucleotide/oligosaccharide binding-fold subdomain and an alpha-helical subdomain. The C-terminal domain adopts an alphabeta-fold very similar to the C-terminal domain of elongation factor (eEF) 1Balpha, the guanine-nucleotide exchange factor for eEF1A. The structural and functional similarities found between eIF2alpha/eIF2gamma and eEF1Balpha/eEF1A suggest a model for the interaction of eIF2alpha with eIF2gamma, and eIF2 with Met-tRNAiMet. It further indicates a previously unrecognized evolutionary lineage of eIF2alpha/gamma from the functionally related elongation factor eEF1Balpha/eEF1A complex.
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The line below this paragraph, {{ABSTRACT_PUBMED_15341733}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15341733 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15341733}}
==About this Structure==
==About this Structure==
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1Q8K is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q8K OCA].
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1Q8K is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q8K OCA].
==Reference==
==Reference==
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[[Category: Translation]]
[[Category: Translation]]
[[Category: Translation initiation]]
[[Category: Translation initiation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:59:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:38:59 2008''

Revision as of 17:39, 27 July 2008

Image:1q8k.png


PDB ID 1q8k

Drag the structure with the mouse to rotate
1q8k, 15 NMR models ()
Gene: EIF2S1 OR EIF2A (Homo sapiens)
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



Solution structure of alpha subunit of human eIF2

Template:ABSTRACT PUBMED 15341733

About this Structure

1Q8K is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure of human initiation factor eIF2alpha reveals homology to the elongation factor eEF1B., Ito T, Marintchev A, Wagner G, Structure. 2004 Sep;12(9):1693-704. PMID:15341733

Page seeded by OCA on Sun Jul 27 20:38:59 2008

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