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2jmd

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[[Image:2jmd.gif|left|200px]]
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{{STRUCTURE_2jmd| PDB=2jmd | SCENE= }}
{{STRUCTURE_2jmd| PDB=2jmd | SCENE= }}
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'''Solution Structure of the Ring Domain of Human TRAF6'''
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===Solution Structure of the Ring Domain of Human TRAF6===
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==Overview==
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A key step in the signaling cascade responsible for activation of the transcription factor NF-kappaB involves Lys63-linked polyubiquitination of TRAF6. Covalent attachment of ubiquitin (Ub) to TRAF6, and subsequent poly(Ub) chain synthesis, is catalyzed by the hUev1a-hUbc13 heterodimer. hUbc13 is a catalytically competent E2 enzyme, and hUev1a is an E2-like protein that binds substrate Ub. The hUev1a-hUbc13 heterodimer is targeted to TRAF6 through interactions between hUbc13 and the N-terminal RING domain from TRAF6. Nuclear magnetic resonance (NMR) spectroscopy was used to determine the solution state structure of the RING domain from human TRAF6, and the interaction between hUbc13 and TRAF6 was characterized using NMR chemical shift mapping. The main-chain dynamics of the RING domain from TRAF6 were studied using (15)N NMR relaxation. Analysis of the main-chain dynamics data indicates that residues within the alpha-helix and beta-sheet of the RING domain are as rigid as regions of canonical secondary structure in larger proteins, consistent with the biological role of RING-domain E3 proteins, which requires that the E3 contain a recognition site for recruitment of E2 ubiquitin conjugation enzymes.
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(as it appears on PubMed at http://www.pubmed.gov), where 17327397 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17327397}}
==About this Structure==
==About this Structure==
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2JMD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JMD OCA].
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2JMD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JMD OCA].
==Reference==
==Reference==
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[[Category: Zinc-binding]]
[[Category: Zinc-binding]]
[[Category: Zn2+ coordination]]
[[Category: Zn2+ coordination]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:01:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:18:34 2008''

Revision as of 18:18, 27 July 2008

Image:2jmd.png

Template:STRUCTURE 2jmd

Solution Structure of the Ring Domain of Human TRAF6

Template:ABSTRACT PUBMED 17327397

About this Structure

2JMD is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Structure, interactions, and dynamics of the RING domain from human TRAF6., Mercier P, Lewis MJ, Hau DD, Saltibus LF, Xiao W, Spyracopoulos L, Protein Sci. 2007 Apr;16(4):602-14. Epub 2007 Feb 27. PMID:17327397

Page seeded by OCA on Sun Jul 27 21:18:34 2008

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