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1s7n

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[[Image:1s7n.gif|left|200px]]
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{{STRUCTURE_1s7n| PDB=1s7n | SCENE= }}
{{STRUCTURE_1s7n| PDB=1s7n | SCENE= }}
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'''Ribosomal L7/L12 alpha-N-protein acetyltransferase in complex with Coenzyme A (CoA free sulfhydryl)'''
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===Ribosomal L7/L12 alpha-N-protein acetyltransferase in complex with Coenzyme A (CoA free sulfhydryl)===
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==Overview==
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RimL is responsible for converting the prokaryotic ribosomal protein from L12 to L7 by acetylation of its N-terminal amino group. We demonstrate that purified RimL is capable of posttranslationally acetylating L12, exhibiting a V(max) of 21 min(-1). We have also determined the apostructure of RimL from Salmonella typhimurium and its complex with coenzyme A, revealing a homodimeric oligomer with structural similarity to other Gcn5-related N-acetyltransferase superfamily members. A large central trough located at the dimer interface provides sufficient room to bind both L12 N-terminal helices. Structural and biochemical analysis indicates that RimL proceeds by single-step transfer rather than a covalent-enzyme intermediate. This is the first structure of a Gcn5-related N-acetyltransferase family member with demonstrated activity toward a protein N(alpha)-amino group and is a first step toward understanding the molecular basis for N(alpha)acetylation and its function in cellular regulation.
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(as it appears on PubMed at http://www.pubmed.gov), where 15817456 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15817456}}
==About this Structure==
==About this Structure==
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[[Category: Gnat]]
[[Category: Gnat]]
[[Category: L7/l12]]
[[Category: L7/l12]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:23:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:21:25 2008''

Revision as of 18:21, 27 July 2008

Image:1s7n.png

Template:STRUCTURE 1s7n

Ribosomal L7/L12 alpha-N-protein acetyltransferase in complex with Coenzyme A (CoA free sulfhydryl)

Template:ABSTRACT PUBMED 15817456

About this Structure

1S7N is a Single protein structure of sequence from Salmonella typhimurium lt2. Full crystallographic information is available from OCA.

Reference

A novel dimeric structure of the RimL Nalpha-acetyltransferase from Salmonella typhimurium., Vetting MW, de Carvalho LP, Roderick SL, Blanchard JS, J Biol Chem. 2005 Jun 10;280(23):22108-14. Epub 2005 Apr 6. PMID:15817456

Page seeded by OCA on Sun Jul 27 21:21:25 2008

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