1tqi

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{{STRUCTURE_1tqi| PDB=1tqi | SCENE= }}
{{STRUCTURE_1tqi| PDB=1tqi | SCENE= }}
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'''Crystal Structure of A. Fulgidus Rio2 Serine Protein Kinase'''
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===Crystal Structure of A. Fulgidus Rio2 Serine Protein Kinase===
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==Overview==
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The RIO family of atypical serine/threonine kinases contains two subfamilies, Rio1 and Rio2, highly conserved from archaea to man. Both RIO proteins from Saccharomyces cerevisiae catalyze serine phosphorylation in vitro, and the presence of conserved catalytic residues is required for cell viability. The activity of Rio2 is necessary for rRNA cleavage in 40S ribosomal subunit maturation. We solved the X-ray crystal structure of Archaeoglobus fulgidus Rio2, with and without bound nucleotides, at 2.0 A resolution. The C-terminal RIO domain is indeed structurally homologous to protein kinases, although it differs from known serine kinases in ATP binding and lacks the regions important for substrate binding. Unexpectedly, the N-terminal Rio2-specific domain contains a winged helix fold, seen primarily in DNA-binding proteins. These discoveries have implications in determining the target and function of RIO proteins and define a distinct new family of protein kinases.
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{{ABSTRACT_PUBMED_15341724}}
==About this Structure==
==About this Structure==
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[[Category: Wlodawer, A.]]
[[Category: Wlodawer, A.]]
[[Category: Serine kinase]]
[[Category: Serine kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:15:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:34:46 2008''

Revision as of 18:34, 27 July 2008

Image:1tqi.png

Template:STRUCTURE 1tqi

Crystal Structure of A. Fulgidus Rio2 Serine Protein Kinase

Template:ABSTRACT PUBMED 15341724

About this Structure

1TQI is a Single protein structure of sequence from Archaeoglobus fulgidus dsm 4304. Full crystallographic information is available from OCA.

Reference

Crystal structure of A. fulgidus Rio2 defines a new family of serine protein kinases., LaRonde-LeBlanc N, Wlodawer A, Structure. 2004 Sep;12(9):1585-94. PMID:15341724

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