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1ydp

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{{STRUCTURE_1ydp| PDB=1ydp | SCENE= }}
{{STRUCTURE_1ydp| PDB=1ydp | SCENE= }}
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'''1.9A crystal structure of HLA-G'''
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===1.9A crystal structure of HLA-G===
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==Overview==
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HLA-G is a nonclassical major histocompatibility complex class I (MHC-I) molecule that is primarily expressed at the fetal-maternal interface, where it is thought to play a role in protecting the fetus from the maternal immune response. HLA-G binds a limited repertoire of peptides and interacts with the inhibitory leukocyte Ig-like receptors LIR-1 and LIR-2 and possibly with certain natural killer cell receptors. To gain further insights into HLA-G function, we determined the 1.9-A structure of a monomeric HLA-G complexed to a natural endogenous peptide ligand from histone H2A (RIIPRHLQL). An extensive network of contacts between the peptide and the antigen-binding cleft reveal a constrained mode of binding reminiscent of the nonclassical HLA-E molecule, thereby providing a structural basis for the limited peptide repertoire of HLA-G. The alpha3 domain of HLA-G, a candidate binding site for the LIR-1 and -2 inhibitory receptors, is structurally distinct from the alpha3 domains of classical MHC-I molecules, providing a rationale for the observed affinity differences for these ligands. The structural data suggest a head-to-tail mode of dimerization, mediated by an intermolecular disulfide bond, that is consistent with the observation of HLA-G dimers on the cell surface.
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(as it appears on PubMed at http://www.pubmed.gov), where 15718280 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15718280}}
==About this Structure==
==About this Structure==
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[[Category: Rossjohn, J.]]
[[Category: Rossjohn, J.]]
[[Category: Immune system]]
[[Category: Immune system]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:11:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:35:46 2008''

Revision as of 18:35, 27 July 2008

Image:1ydp.png

Template:STRUCTURE 1ydp

1.9A crystal structure of HLA-G

Template:ABSTRACT PUBMED 15718280

About this Structure

1YDP is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of HLA-G: a nonclassical MHC class I molecule expressed at the fetal-maternal interface., Clements CS, Kjer-Nielsen L, Kostenko L, Hoare HL, Dunstone MA, Moses E, Freed K, Brooks AG, Rossjohn J, McCluskey J, Proc Natl Acad Sci U S A. 2005 Mar 1;102(9):3360-5. Epub 2005 Feb 17. PMID:15718280

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