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1o71

From Proteopedia

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{{STRUCTURE_1o71| PDB=1o71 | SCENE= }}
{{STRUCTURE_1o71| PDB=1o71 | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE WATER-SOLUBLE STATE OF THE PORE-FORMING CYTOLYSIN STICHOLYSIN II COMPLEXED WITH GLYCEROL'''
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===CRYSTAL STRUCTURE OF THE WATER-SOLUBLE STATE OF THE PORE-FORMING CYTOLYSIN STICHOLYSIN II COMPLEXED WITH GLYCEROL===
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==Overview==
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Sticholysin II (StnII) is a pore-forming protein (PFP) produced by the sea anemone Stichodactyla helianthus. We found out that StnII exists in a monomeric soluble state but forms tetramers in the presence of a lipidic interface. Both structures have been independently determined at 1.7 A and 18 A resolution, respectively, by using X-ray crystallography and electron microscopy of two-dimensional crystals. Besides, the structure of soluble StnII complexed with phosphocholine, determined at 2.4 A resolution, reveals a phospholipid headgroup binding site, which is located in a region with an unusually high abundance of aromatic residues. Fitting of the atomic model into the electron microscopy density envelope suggests that while the beta sandwich structure of the protein remains intact upon oligomerization, the N-terminal region and a flexible and highly basic loop undergo significant conformational changes. These results provide the structural basis for the membrane recognition step of actinoporins and unexpected insights into the oligomerization step.
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(as it appears on PubMed at http://www.pubmed.gov), where 14604522 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14604522}}
==About this Structure==
==About this Structure==
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[[Category: Membrane interaction]]
[[Category: Membrane interaction]]
[[Category: Pore-forming toxin]]
[[Category: Pore-forming toxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:27:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:37:39 2008''

Revision as of 18:37, 27 July 2008

Image:1o71.png

Template:STRUCTURE 1o71

CRYSTAL STRUCTURE OF THE WATER-SOLUBLE STATE OF THE PORE-FORMING CYTOLYSIN STICHOLYSIN II COMPLEXED WITH GLYCEROL

Template:ABSTRACT PUBMED 14604522

About this Structure

1O71 is a Single protein structure of sequence from Stichodactyla helianthus. Full crystallographic information is available from OCA.

Reference

Crystal and electron microscopy structures of sticholysin II actinoporin reveal insights into the mechanism of membrane pore formation., Mancheno JM, Martin-Benito J, Martinez-Ripoll M, Gavilanes JG, Hermoso JA, Structure. 2003 Nov;11(11):1319-28. PMID:14604522

Page seeded by OCA on Sun Jul 27 21:37:39 2008

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