This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1nzk

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1nzk.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1nzk.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1nzk| PDB=1nzk | SCENE= }}
{{STRUCTURE_1nzk| PDB=1nzk | SCENE= }}
-
'''Crystal Structure of a Multiple Mutant (L44F, L73V, V109L, L111I, C117V) of Human Acidic Fibroblast Growth Factor'''
+
===Crystal Structure of a Multiple Mutant (L44F, L73V, V109L, L111I, C117V) of Human Acidic Fibroblast Growth Factor===
-
==Overview==
+
<!--
-
An alternative core packing group, involving a set of five positions, has been introduced into human acidic FGF-1. This alternative group was designed so as to constrain the primary structure within the core region to the same threefold symmetry present in the tertiary structure of the protein fold (the beta-trefoil superfold). The alternative core is essentially indistinguishable from the WT core with regard to structure, stability, and folding kinetics. The results show that the beta-trefoil superfold is compatible with a threefold symmetric constraint on the core region, as might be the case if the superfold arose as a result of gene duplication/fusion events. Furthermore, this new core arrangement can form the basis of a structural "building block" that can greatly simplify the de novo design of beta-trefoil proteins by using symmetric structural complementarity. Remaining asymmetry within the core appears to be related to asymmetry in the tertiary structure associated with receptor and heparin binding functionality of the growth factor.
+
The line below this paragraph, {{ABSTRACT_PUBMED_14627732}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 14627732 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_14627732}}
==About this Structure==
==About this Structure==
Line 27: Line 31:
[[Category: Logan, T M.]]
[[Category: Logan, T M.]]
[[Category: Beta-trefoil]]
[[Category: Beta-trefoil]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:10:49 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:52:54 2008''

Revision as of 18:52, 27 July 2008

Image:1nzk.png

Template:STRUCTURE 1nzk

Crystal Structure of a Multiple Mutant (L44F, L73V, V109L, L111I, C117V) of Human Acidic Fibroblast Growth Factor

Template:ABSTRACT PUBMED 14627732

About this Structure

1NZK is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Accommodation of a highly symmetric core within a symmetric protein superfold., Brych SR, Kim J, Logan TM, Blaber M, Protein Sci. 2003 Dec;12(12):2704-18. PMID:14627732

Page seeded by OCA on Sun Jul 27 21:52:54 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1nzk"
Personal tools