This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1ygt

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1ygt.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1ygt.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1ygt| PDB=1ygt | SCENE= }}
{{STRUCTURE_1ygt| PDB=1ygt | SCENE= }}
-
'''Dynein Light Chain TcTex-1'''
+
===Dynein Light Chain TcTex-1===
-
==Overview==
+
<!--
-
TcTex-1, one of three dynein light chains of the dynein motor complex, has been implicated in targeting and binding cargoes to cytoplasmic dynein for retrograde or apical transport. Interactions between TcTex-1 and a diverse set of proteins such as the dynein intermediate chain, Fyn, DOC2, FIP1, the poliovirus receptor, CD155, and the rhodopsin cytoplasmic tail have been reported; yet, despite the broad range of targets, a consensus binding sequence remains uncertain. Consequently, we have solved the crystal structure of the full-length Drosophila homolog of TcTex-1 to 1.7 A resolution using MAD phasing to gain insight into its function and target specificity. The structure is homodimeric with a domain swapping of beta-strand 2 and has a fold similar to the dynein light chain, LC8. Based on structural alignment, the TcTex-1 and LC8 sequences show no identity, although the root mean square deviation between secondary structural elements is less than 1.6 A. Moreover, the N terminus, which is equivalent to beta-strand 1 in LC8, is splayed out and binds to a crystallographic dimer as an anti-parallel beta-strand at the same position as the neuronal nitric-oxide synthase peptide in the LC8 complex. Similarity to LC8 and comparison to the LC8-neuronal nitricoxide synthase complex suggest that TcTex-1 binds its targets in a similar manner as LC8 and provides insight to the lack of strict sequence identity among the targets for TcTex-1.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15701632}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15701632 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15701632}}
==About this Structure==
==About this Structure==
Line 26: Line 30:
[[Category: Xie, H.]]
[[Category: Xie, H.]]
[[Category: Domain swapping]]
[[Category: Domain swapping]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:17:59 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 22:12:29 2008''

Revision as of 19:12, 27 July 2008

Image:1ygt.png

Template:STRUCTURE 1ygt

Dynein Light Chain TcTex-1

Template:ABSTRACT PUBMED 15701632

About this Structure

1YGT is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

Crystal structure of dynein light chain TcTex-1., Williams JC, Xie H, Hendrickson WA, J Biol Chem. 2005 Jun 10;280(23):21981-6. Epub 2005 Feb 8. PMID:15701632

Page seeded by OCA on Sun Jul 27 22:12:29 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ygt"
Personal tools