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2ff4

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{{STRUCTURE_2ff4| PDB=2ff4 | SCENE= }}
{{STRUCTURE_2ff4| PDB=2ff4 | SCENE= }}
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'''Mycobacterium tuberculosis EmbR in complex with low affinity phosphopeptide'''
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===Mycobacterium tuberculosis EmbR in complex with low affinity phosphopeptide===
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==Overview==
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Ser/Thr phosphorylation has emerged as a critical regulatory mechanism in a number of bacteria, including Mycobacterium tuberculosis. This problematic pathogen encodes 11 eukaryotic-like Ser/Thr kinases, yet few substrates or signaling targets have been characterized. Here, we report the structure of EmbR (2.0 A), a putative transcriptional regulator of key arabinosyltransferases (EmbC, -A, and -B), and an endogenous substrate of the Ser/Thr-kinase PknH. EmbR presents a unique domain architecture: the N-terminal winged-helix DNA-binding domain forms an extensive interface with the all-helical central bacterial transcriptional activation domain and is positioned adjacent to the regulatory C-terminal forkhead-associated (FHA) domain, which mediates binding to a Thr-phosphorylated site in PknH. The structure in complex with a phospho-peptide (1.9 A) reveals a conserved mode of phospho-threonine recognition by the FHA domain and evidence for specific recognition of the cognate kinase. The present structures suggest hypotheses as to how EmbR might propagate the phospho-relay signal from its cognate kinase, while serving as a template for the structurally uncharacterized Streptomyces antibiotic regulatory protein family of transcription factors.
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(as it appears on PubMed at http://www.pubmed.gov), where 16477027 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16477027}}
==About this Structure==
==About this Structure==
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[[Category: Tetratricopeptide repeat]]
[[Category: Tetratricopeptide repeat]]
[[Category: Winged-helix]]
[[Category: Winged-helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:49:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 22:28:01 2008''

Revision as of 19:28, 27 July 2008

Image:2ff4.png

Template:STRUCTURE 2ff4

Mycobacterium tuberculosis EmbR in complex with low affinity phosphopeptide

Template:ABSTRACT PUBMED 16477027

About this Structure

2FF4 is a Protein complex structure of sequences from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.

Reference

Molecular structure of EmbR, a response element of Ser/Thr kinase signaling in Mycobacterium tuberculosis., Alderwick LJ, Molle V, Kremer L, Cozzone AJ, Dafforn TR, Besra GS, Futterer K, Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2558-63. Epub 2006 Feb 13. PMID:16477027

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