1yaa

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[[Image:1yaa.gif|left|200px]]
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{{STRUCTURE_1yaa| PDB=1yaa | SCENE= }}
{{STRUCTURE_1yaa| PDB=1yaa | SCENE= }}
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'''ASPARTATE AMINOTRANSFERASE FROM SACCHAROMYCES CEREVISIAE CYTOPLASM'''
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===ASPARTATE AMINOTRANSFERASE FROM SACCHAROMYCES CEREVISIAE CYTOPLASM===
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==Overview==
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The crystal structure of Saccharomyces cerevisiae cytoplasmic aspartate aminotransferase (EC 2.6.1.1) has been determined to 2.05 A resolution in the presence of the cofactor pyridoxal-5'-phosphate and the competitive inhibitor maleate. The structure was solved by the method of molecular replacement. The final value of the crystallographic R-factor after refinement was 23.1% with good geometry of the final model. The yeast cytoplasmic enzyme is a homodimer with two identical active sites containing residues from each subunit. It is found in the "closed" conformation with a bound maleate inhibitor in each active site. It shares the same three-dimensional fold and active site residues as the aspartate aminotransferases from Escherichia coli, chicken cytoplasm, and chicken mitochondria, although it shares less than 50% sequence identity with any of them. The availability of four similar enzyme structures from distant regions of the evolutionary tree provides a measure of tolerated changes that can arise during millions of years of evolution.
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(as it appears on PubMed at http://www.pubmed.gov), where 9655342 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9655342}}
==About this Structure==
==About this Structure==
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[[Category: Aminotransferase]]
[[Category: Aminotransferase]]
[[Category: Transferase]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:04:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 22:57:53 2008''

Revision as of 19:57, 27 July 2008

Image:1yaa.png

Template:STRUCTURE 1yaa

ASPARTATE AMINOTRANSFERASE FROM SACCHAROMYCES CEREVISIAE CYTOPLASM

Template:ABSTRACT PUBMED 9655342

About this Structure

1YAA is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Crystal structure of Saccharomyces cerevisiae cytosolic aspartate aminotransferase., Jeffery CJ, Barry T, Doonan S, Petsko GA, Ringe D, Protein Sci. 1998 Jun;7(6):1380-7. PMID:9655342

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