2z1d

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{{STRUCTURE_2z1d| PDB=2z1d | SCENE= }}
{{STRUCTURE_2z1d| PDB=2z1d | SCENE= }}
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'''Crystal structure of [NiFe] hydrogenase maturation protein, HypD from Thermococcus kodakaraensis'''
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===Crystal structure of [NiFe] hydrogenase maturation protein, HypD from Thermococcus kodakaraensis===
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==Overview==
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[NiFe] hydrogenase maturation proteins HypC, HypD, and HypE catalyze the insertion and cyanation of the iron center of [NiFe] hydrogenases by an unknown mechanism. We have determined the crystal structures of HypC, HypD, and HypE from Thermococcus kodakaraensis KOD1 at 1.8 A, 2.07 A, and 1.55 A resolution, respectively. The structure of HypD reveals its probable iron binding and active sites for cyanation. An extended conformation of each conserved motif of HypC and HypE allows the essential cysteine residues of both proteins to interact with the active site of HypD. Furthermore, the C-terminal tail of HypE is shown to exist in an ATP-dependent dynamic equilibrium between outward and inward conformations. Unexpectedly, the [4Fe-4S] cluster environment of HypD is quite similar to that of ferredoxin:thioredoxin reductase (FTR), indicating the existence of a redox cascade similar to the FTR system. These results suggest a cyanation reaction mechanism via unique thiol redox signaling in the HypCDE complex.
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{{ABSTRACT_PUBMED_17612488}}
==About this Structure==
==About this Structure==
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[[Category: Watanabe, S.]]
[[Category: Watanabe, S.]]
[[Category: Thiol redox]]
[[Category: Thiol redox]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 19:49:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:03:10 2008''

Revision as of 20:03, 27 July 2008

Image:2z1d.png

Template:STRUCTURE 2z1d

Crystal structure of [NiFe] hydrogenase maturation protein, HypD from Thermococcus kodakaraensis

Template:ABSTRACT PUBMED 17612488

About this Structure

2Z1D is a Single protein structure of sequence from Thermococcus kodakarensis. Full crystallographic information is available from OCA.

Reference

Crystal structures of [NiFe] hydrogenase maturation proteins HypC, HypD, and HypE: insights into cyanation reaction by thiol redox signaling., Watanabe S, Matsumi R, Arai T, Atomi H, Imanaka T, Miki K, Mol Cell. 2007 Jul 6;27(1):29-40. PMID:17612488

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