1r35

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{{STRUCTURE_1r35| PDB=1r35 | SCENE= }}
{{STRUCTURE_1r35| PDB=1r35 | SCENE= }}
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'''MURINE INDUCIBLE NITRIC OXIDE SYNTHASE OXYGENASE DIMER, TETRAHYDROBIOPTERIN AND 4R-FLUORO-N6-ETHANIMIDOYL-L-LYSINE'''
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===MURINE INDUCIBLE NITRIC OXIDE SYNTHASE OXYGENASE DIMER, TETRAHYDROBIOPTERIN AND 4R-FLUORO-N6-ETHANIMIDOYL-L-LYSINE===
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==Overview==
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In the literature, the introduction of fluorine into bioactive molecules has been known to enhance the biological activity relative to the parent molecule. Described in this article is the synthesis of 4R-fluoro-L-NIL (12) and 4,4-difluoro-L-NIL (23) as part of our iNOS program. Both 12 and 23 were found to be selective iNOS inhibitors as shown in Table 2 below. Secondarily, methodology to synthesize orthogonally protected 4-fluoro-L-lysine and 4,4-difluoro-L-lysine has been developed.
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{{ABSTRACT_PUBMED_14599013}}
==About this Structure==
==About this Structure==
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[[Category: Pterin]]
[[Category: Pterin]]
[[Category: Tetrahydrobiopterin]]
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Revision as of 20:16, 27 July 2008

Image:1r35.png

Template:STRUCTURE 1r35

MURINE INDUCIBLE NITRIC OXIDE SYNTHASE OXYGENASE DIMER, TETRAHYDROBIOPTERIN AND 4R-FLUORO-N6-ETHANIMIDOYL-L-LYSINE

Template:ABSTRACT PUBMED 14599013

About this Structure

1R35 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

4-Fluorinated L-lysine analogs as selective i-NOS inhibitors: methodology for introducing fluorine into the lysine side chain., Hallinan EA, Kramer SW, Houdek SC, Moore WM, Jerome GM, Spangler DP, Stevens AM, Shieh HS, Manning PT, Pitzele BS, Org Biomol Chem. 2003 Oct 21;1(20):3527-34. PMID:14599013

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