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1nzg

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{{STRUCTURE_1nzg| PDB=1nzg | SCENE= }}
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'''Crystal structure of A-DNA decamer GCGTA(3ME)ACGC, with a modified 5-methyluridine'''
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===Crystal structure of A-DNA decamer GCGTA(3ME)ACGC, with a modified 5-methyluridine===
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==Overview==
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[structure: see text] Oligonucleotides with a novel, 2'-O-[2-[2-(N,N-dimethylamino)ethoxy]ethyl] (2'-O-DMAEOE) modification have been synthesized. This modification, a cationic analogue of the 2'-O-(2-methoxyethyl) (2'-O-MOE) modification, exhibits high binding affinity to target RNA (but not to DNA) and exceptional resistance to nuclease degradation. Analysis of the crystal structure of a self-complementary oligonucleotide containing a single 2'-O-DMAEOE modification explains the importance of charge factors and gauche effects on the observed antisense properties. 2'-O-DMAEOE modified oligonucleotides are ideal candidates for antisense drugs.
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(as it appears on PubMed at http://www.pubmed.gov), where 12790517 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12790517}}
==About this Structure==
==About this Structure==
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[[Category: A-dna]]
[[Category: A-dna]]
[[Category: Crystal structure]]
[[Category: Crystal structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:10:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:32:17 2008''

Revision as of 20:32, 27 July 2008

Image:1nzg.png

Template:STRUCTURE 1nzg

Crystal structure of A-DNA decamer GCGTA(3ME)ACGC, with a modified 5-methyluridine

Template:ABSTRACT PUBMED 12790517

About this Structure

Full crystallographic information is available from OCA.

Reference

2'-O-[2-[2-(N,N-dimethylamino)ethoxy]ethyl] modified oligonucleotides: symbiosis of charge interaction factors and stereoelectronic effects., Prhavc M, Prakash TP, Minasov G, Cook PD, Egli M, Manoharan M, Org Lett. 2003 Jun 12;5(12):2017-20. PMID:12790517

Page seeded by OCA on Sun Jul 27 23:32:17 2008

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