This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1u33

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1u33.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1u33.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1u33| PDB=1u33 | SCENE= }}
{{STRUCTURE_1u33| PDB=1u33 | SCENE= }}
-
'''In situ extension as an approach for identifying novel alpha-amylase inhibitors'''
+
===In situ extension as an approach for identifying novel alpha-amylase inhibitors===
-
==Overview==
+
<!--
-
A new approach for the discovery and subsequent structural elucidation of oligosaccharide-based inhibitors of alpha-amylases based upon autoglucosylation of known alpha-glucosidase inhibitors is presented. This concept, highly analogous to what is hypothesized to occur with acarbose, is demonstrated with the known alpha-glucosidase inhibitor, d-gluconohydroximino-1,5-lactam. This was transformed from an inhibitor of human pancreatic alpha-amylase with a K(i) value of 18 mm to a trisaccharide analogue with a K(i) value of 25 mum. The three-dimensional structure of this complex was determined by x-ray crystallography and represents the first such structure determined with this class of inhibitors in any alpha-glycosidase. This approach to the discovery and structural analysis of amylase inhibitors should be generally applicable to other endoglucosidases and readily adaptable to a high throughput format.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15304511}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15304511 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15304511}}
==About this Structure==
==About this Structure==
Line 37: Line 41:
[[Category: Human pancreatic alpha-amylase]]
[[Category: Human pancreatic alpha-amylase]]
[[Category: Inhibitor]]
[[Category: Inhibitor]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:42:00 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:58:29 2008''

Revision as of 20:58, 27 July 2008

Image:1u33.png

Template:STRUCTURE 1u33

In situ extension as an approach for identifying novel alpha-amylase inhibitors

Template:ABSTRACT PUBMED 15304511

About this Structure

1U33 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

In situ extension as an approach for identifying novel alpha-amylase inhibitors., Numao S, Damager I, Li C, Wrodnigg TM, Begum A, Overall CM, Brayer GD, Withers SG, J Biol Chem. 2004 Nov 12;279(46):48282-91. Epub 2004 Aug 10. PMID:15304511

Page seeded by OCA on Sun Jul 27 23:58:29 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1u33"
Personal tools