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2o3m

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{{STRUCTURE_2o3m| PDB=2o3m | SCENE= }}
{{STRUCTURE_2o3m| PDB=2o3m | SCENE= }}
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'''Monomeric G-DNA tetraplex from human C-kit promoter'''
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===Monomeric G-DNA tetraplex from human C-kit promoter===
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==Overview==
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The c-kit oncogene is an important target in the treatment of gastrointestinal tumors. A potential approach to inhibition of the expression of this gene involves selective stabilization of G-quadruplex structures that may be induced to form in the c-kit promoter region. Here we report on the structure of an unprecedented intramolecular G-quadruplex formed by a G-rich sequence in the c-kit promoter in K+ solution. The structure represents a new folding topology with several unique features. Most strikingly, an isolated guanine is involved in G-tetrad core formation, despite the presence of four three-guanine tracts. There are four loops: two single-residue double-chain-reversal loops, a two-residue loop, and a five-residue stem-loop, which contain base-pairing alignments. This unique structural scaffold provides a highly specific platform for the future design of ligands specifically targeted to the promoter DNA of c-kit.
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(as it appears on PubMed at http://www.pubmed.gov), where 17362008 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17362008}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O3M OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O3M OCA].
==Reference==
==Reference==
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[[Category: G-tetrad;parallel g-quadruplex]]
[[Category: G-tetrad;parallel g-quadruplex]]
[[Category: Single-residue cha reversal,5-nucleotide snap-back loops;broken strand topolog]]
[[Category: Single-residue cha reversal,5-nucleotide snap-back loops;broken strand topolog]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 10:17:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:04:22 2008''

Revision as of 21:04, 27 July 2008

Image:2o3m.png

Template:STRUCTURE 2o3m

Monomeric G-DNA tetraplex from human C-kit promoter

Template:ABSTRACT PUBMED 17362008

About this Structure

Full experimental information is available from OCA.

Reference

Structure of an unprecedented G-quadruplex scaffold in the human c-kit promoter., Phan AT, Kuryavyi V, Burge S, Neidle S, Patel DJ, J Am Chem Soc. 2007 Apr 11;129(14):4386-92. Epub 2007 Mar 16. PMID:17362008

Page seeded by OCA on Mon Jul 28 00:04:22 2008

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