1tco

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{{STRUCTURE_1tco| PDB=1tco | SCENE= }}
{{STRUCTURE_1tco| PDB=1tco | SCENE= }}
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'''TERNARY COMPLEX OF A CALCINEURIN A FRAGMENT, CALCINEURIN B, FKBP12 AND THE IMMUNOSUPPRESSANT DRUG FK506 (TACROLIMUS)'''
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===TERNARY COMPLEX OF A CALCINEURIN A FRAGMENT, CALCINEURIN B, FKBP12 AND THE IMMUNOSUPPRESSANT DRUG FK506 (TACROLIMUS)===
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==Overview==
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The X-ray structure of the ternary complex of a calcineurin A fragment, calcineurin B, FKBP12, and the immunosuppressant drug FK506 (also known as tacrolimus) has been determined at 2.5 A resolution, providing a description of how FK506 functions at the atomic level. In the structure, the FKBP12-FK506 binary complex does not contact the phosphatase active site on calcineurin A that is more than 10 A removed. Instead, FKBP12-FK506 is so positioned that it can inhibit the dephosphorylation of its macromolecular substrates by physically hindering their approach to the active site. The ternary complex described here represents the three-dimensional structure of a Ser/Thr protein phosphatase and provides a structural basis for understanding calcineurin inhibition by FKBP12-FK506.
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{{ABSTRACT_PUBMED_7543369}}
==About this Structure==
==About this Structure==
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[[Category: Thomson, J A.]]
[[Category: Thomson, J A.]]
[[Category: Immunosuppressant]]
[[Category: Immunosuppressant]]
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Revision as of 21:08, 27 July 2008

Image:1tco.png

Template:STRUCTURE 1tco

TERNARY COMPLEX OF A CALCINEURIN A FRAGMENT, CALCINEURIN B, FKBP12 AND THE IMMUNOSUPPRESSANT DRUG FK506 (TACROLIMUS)

Template:ABSTRACT PUBMED 7543369

About this Structure

1TCO is a Protein complex structure of sequences from Bos taurus. Full crystallographic information is available from OCA.

Reference

X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex., Griffith JP, Kim JL, Kim EE, Sintchak MD, Thomson JA, Fitzgibbon MJ, Fleming MA, Caron PR, Hsiao K, Navia MA, Cell. 1995 Aug 11;82(3):507-22. PMID:7543369

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