1p8j

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{{STRUCTURE_1p8j| PDB=1p8j | SCENE= }}
{{STRUCTURE_1p8j| PDB=1p8j | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE PROPROTEIN CONVERTASE FURIN'''
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===CRYSTAL STRUCTURE OF THE PROPROTEIN CONVERTASE FURIN===
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==Overview==
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In eukaryotes, many essential secreted proteins and peptide hormones are excised from larger precursors by members of a class of calcium-dependent endoproteinases, the prohormone-proprotein convertases (PCs). Furin, the best-characterized member of the mammalian PC family, has essential functions in embryogenesis and homeostasis but is also implicated in various pathologies such as tumor metastasis, neurodegeneration and various bacterial and viral diseases caused by such pathogens as anthrax and pathogenic Ebola virus strains. Furin cleaves protein precursors with narrow specificity following basic Arg-Xaa-Lys/Arg-Arg-like motifs. The 2.6 A crystal structure of the decanoyl-Arg-Val-Lys-Arg-chloromethylketone (dec-RVKR-cmk)-inhibited mouse furin ectodomain, the first PC structure, reveals an eight-stranded jelly-roll P domain associated with the catalytic domain. Contoured surface loops shape the active site by cleft, thus explaining furin's stringent requirement for arginine at P1 and P4, and lysine at P2 sites by highly charge-complementary pockets. The structure also explains furin's preference for basic residues at P3, P5 and P6 sites. This structure will aid in the rational design of antiviral and antibacterial drugs.
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(as it appears on PubMed at http://www.pubmed.gov), where 12794637 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12794637}}
==About this Structure==
==About this Structure==
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[[Category: Prohormone convertase]]
[[Category: Prohormone convertase]]
[[Category: Spc1]]
[[Category: Spc1]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:49:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:18:10 2008''

Revision as of 21:18, 27 July 2008

Image:1p8j.png

Template:STRUCTURE 1p8j

CRYSTAL STRUCTURE OF THE PROPROTEIN CONVERTASE FURIN

Template:ABSTRACT PUBMED 12794637

About this Structure

1P8J is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

The crystal structure of the proprotein processing proteinase furin explains its stringent specificity., Henrich S, Cameron A, Bourenkov GP, Kiefersauer R, Huber R, Lindberg I, Bode W, Than ME, Nat Struct Biol. 2003 Jul;10(7):520-6. PMID:12794637

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