2cw0

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{{STRUCTURE_2cw0| PDB=2cw0 | SCENE= }}
{{STRUCTURE_2cw0| PDB=2cw0 | SCENE= }}
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'''Crystal structure of Thermus thermophilus RNA polymerase holoenzyme at 3.3 angstroms resolution'''
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===Crystal structure of Thermus thermophilus RNA polymerase holoenzyme at 3.3 angstroms resolution===
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==Overview==
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We define the target, mechanism, and structural basis of inhibition of bacterial RNA polymerase (RNAP) by the tetramic acid antibiotic streptolydigin (Stl). Stl binds to a site adjacent to but not overlapping the RNAP active center and stabilizes an RNAP-active-center conformational state with a straight-bridge helix. The results provide direct support for the proposals that alternative straight-bridge-helix and bent-bridge-helix RNAP-active-center conformations exist and that cycling between straight-bridge-helix and bent-bridge-helix RNAP-active-center conformations is required for RNAP function. The results set bounds on models for RNAP function and suggest strategies for design of novel antibacterial agents.
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(as it appears on PubMed at http://www.pubmed.gov), where 16122422 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16122422}}
==About this Structure==
==About this Structure==
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[[Category: Rna polymerase holoenzyme]]
[[Category: Rna polymerase holoenzyme]]
[[Category: Transcription]]
[[Category: Transcription]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 23:11:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:20:38 2008''

Revision as of 21:20, 27 July 2008

Image:2cw0.png

Template:STRUCTURE 2cw0

Crystal structure of Thermus thermophilus RNA polymerase holoenzyme at 3.3 angstroms resolution

Template:ABSTRACT PUBMED 16122422

About this Structure

2CW0 is a Protein complex structure of sequences from Thermus thermophilus. Full crystallographic information is available from OCA.

Reference

Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation., Tuske S, Sarafianos SG, Wang X, Hudson B, Sineva E, Mukhopadhyay J, Birktoft JJ, Leroy O, Ismail S, Clark AD Jr, Dharia C, Napoli A, Laptenko O, Lee J, Borukhov S, Ebright RH, Arnold E, Cell. 2005 Aug 26;122(4):541-52. PMID:16122422

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