1zxc

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[[Image:1zxc.gif|left|200px]]
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{{Seed}}
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[[Image:1zxc.png|left|200px]]
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{{STRUCTURE_1zxc| PDB=1zxc | SCENE= }}
{{STRUCTURE_1zxc| PDB=1zxc | SCENE= }}
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'''Crystal structure of catalytic domain of TNF-alpha converting enzyme (TACE) with inhibitor'''
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===Crystal structure of catalytic domain of TNF-alpha converting enzyme (TACE) with inhibitor===
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==Overview==
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The SAR of a series of potent sulfonamide hydroxamate TACE inhibitors bearing a butynyloxy P1' group was explored. In particular, compound 5k has excellent in vitro potency against TACE enzyme and in cells, and oral activity in an in vivo model of TNF-alpha production and a collagen-induced arthritis model.
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The line below this paragraph, {{ABSTRACT_PUBMED_16084720}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16084720 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16084720}}
==About this Structure==
==About this Structure==
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[[Category: Tace/adam-17]]
[[Category: Tace/adam-17]]
[[Category: Zn-endopeptidase]]
[[Category: Zn-endopeptidase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:11:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:29:18 2008''

Revision as of 21:29, 27 July 2008

Template:STRUCTURE 1zxc

Crystal structure of catalytic domain of TNF-alpha converting enzyme (TACE) with inhibitor

Template:ABSTRACT PUBMED 16084720

About this Structure

1ZXC is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Acetylenic TACE inhibitors. Part 2: SAR of six-membered cyclic sulfonamide hydroxamates., Levin JI, Chen JM, Laakso LM, Du M, Du X, Venkatesan AM, Sandanayaka V, Zask A, Xu J, Xu W, Zhang Y, Skotnicki JS, Bioorg Med Chem Lett. 2005 Oct 1;15(19):4345-9. PMID:16084720

Page seeded by OCA on Mon Jul 28 00:29:18 2008

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