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2j1u

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[[Image:2j1u.jpg|left|200px]]
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{{Seed}}
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[[Image:2j1u.png|left|200px]]
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{{STRUCTURE_2j1u| PDB=2j1u | SCENE= }}
{{STRUCTURE_2j1u| PDB=2j1u | SCENE= }}
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'''STRUCTURE OF A STREPTOCOCCUS PNEUMONIAE FUCOSE BINDING MODULE IN COMPLEX WITH THE BLOOD GROUP A-TETRASACCHARIDE'''
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===STRUCTURE OF A STREPTOCOCCUS PNEUMONIAE FUCOSE BINDING MODULE IN COMPLEX WITH THE BLOOD GROUP A-TETRASACCHARIDE===
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==Overview==
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The Streptococcus pneumoniae fucose utilization operon includes a gene encoding a virulence factor that belongs to family 98 in the glycoside hydrolase classification. This protein contains a C-terminal triplet of fucose binding modules that have significant amino acid sequence identity with the Anguilla anguilla fucolectin. Functional studies of these fucose binding modules reveal binding to fucosylated oligosaccharides and suggest the importance of multivalent binding. The high resolution crystal structures of ligand bound forms of one fucose binding module uncovers the molecular basis of fucose, ABH blood group antigen, and Lewisy antigen binding. These studies are extended by fluorescence microscopy to show specific binding to mouse lung tissue. These modules define a new family of carbohydrate binding modules now classified as family 47.
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The line below this paragraph, {{ABSTRACT_PUBMED_16987809}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16987809 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16987809}}
==About this Structure==
==About this Structure==
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[[Category: Carbohydrate-binding protein]]
[[Category: Carbohydrate-binding protein]]
[[Category: Sugar binding protein]]
[[Category: Sugar binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:13:45 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:54:57 2008''

Revision as of 21:55, 27 July 2008

Image:2j1u.png

Template:STRUCTURE 2j1u

STRUCTURE OF A STREPTOCOCCUS PNEUMONIAE FUCOSE BINDING MODULE IN COMPLEX WITH THE BLOOD GROUP A-TETRASACCHARIDE

Template:ABSTRACT PUBMED 16987809

About this Structure

2J1U is a Single protein structure of sequence from Streptococcus pneumoniae. Full crystallographic information is available from OCA.

Reference

Blood group antigen recognition by a Streptococcus pneumoniae virulence factor., Boraston AB, Wang D, Burke RD, J Biol Chem. 2006 Nov 17;281(46):35263-71. Epub 2006 Sep 20. PMID:16987809

Page seeded by OCA on Mon Jul 28 00:54:57 2008

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