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1t0c

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[[Image:1t0c.gif|left|200px]]
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{{Seed}}
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[[Image:1t0c.png|left|200px]]
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{{STRUCTURE_1t0c| PDB=1t0c | SCENE= }}
{{STRUCTURE_1t0c| PDB=1t0c | SCENE= }}
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'''Solution Structure of Human Proinsulin C-Peptide'''
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===Solution Structure of Human Proinsulin C-Peptide===
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==Overview==
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The C-peptide of proinsulin is important for the biosynthesis of insulin, but has been considered for a long time to be biologically inert. Recent studies in diabetic patients have stimulated a new debate about its possible regulatory role, suggesting that it is a hormonally active peptide. We describe structural studies of the C-peptide using 2D NMR spectroscopy. In aqueous solution, the NOE patterns and chemical shifts indicate that the ensemble is a nonrandom structure and contains substructures with defined local conformations. These are more clearly visible in 50% H2O/50% 2,2,2-trifluoroethanol. The N-terminal region (residues 2-5) forms a type I beta-turn, whereas the C-terminal region (residues 27-31) presents the most well-defined structure of the whole molecule including a type III'beta-turn. The C-terminal pentapeptide (EGSLQ) has been suggested to be responsible for chiral interactions with an as yet uncharacterized, probably a G-protein-coupled, receptor. The three central regions of the molecule (residues 9-12, 15-18 and 22-25) show tendencies to form beta-bends. We propose that the structure described here for the C-terminal pentapeptide is consistent with the previously postulated CA knuckle, believed to represent the active site of the C-peptide of human proinsulin.
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The line below this paragraph, {{ABSTRACT_PUBMED_16098208}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16098208 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16098208}}
==Disease==
==Disease==
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==About this Structure==
==About this Structure==
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1T0C is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T0C OCA].
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1T0C is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T0C OCA].
==Reference==
==Reference==
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[[Category: Type i beta-turn]]
[[Category: Type i beta-turn]]
[[Category: Type iii' beta-turn]]
[[Category: Type iii' beta-turn]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:20:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:55:39 2008''

Revision as of 21:55, 27 July 2008

Image:1t0c.png

Template:STRUCTURE 1t0c

Contents

Solution Structure of Human Proinsulin C-Peptide

Template:ABSTRACT PUBMED 16098208

Disease

Known disease associated with this structure: Diabetes mellitus, rare form OMIM:[176730], Hyperproinsulinemia, familial OMIM:[176730], MODY, one form OMIM:[176730]

About this Structure

1T0C is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure of human proinsulin C-peptide., Munte CE, Vilela L, Kalbitzer HR, Garratt RC, FEBS J. 2005 Aug;272(16):4284-93. PMID:16098208

Page seeded by OCA on Mon Jul 28 00:55:39 2008

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