1odh

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{{STRUCTURE_1odh| PDB=1odh | SCENE= }}
{{STRUCTURE_1odh| PDB=1odh | SCENE= }}
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'''STRUCTURE OF THE GCM DOMAIN BOUND TO DNA'''
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===STRUCTURE OF THE GCM DOMAIN BOUND TO DNA===
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==Overview==
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Glia cell missing (GCM) transcription factors form a small family of transcriptional regulators in metazoans. The prototypical Drosophila GCM protein directs the differentiation of neuron precursor cells into glia cells, whereas mammalian GCM proteins are involved in placenta and parathyroid development. GCM proteins share a highly conserved 150 amino acid residue region responsible for DNA binding, known as the GCM domain. Here we present the crystal structure of the GCM domain from murine GCMa bound to its octameric DNA target site at 2.85 A resolution. The GCM domain exhibits a novel fold consisting of two domains tethered together by one of two structural Zn ions. We observe the novel use of a beta-sheet in DNA recognition, whereby a five- stranded beta-sheet protrudes into the major groove perpendicular to the DNA axis. The structure combined with mutational analysis of the target site and of DNA-contacting residues provides insight into DNA recognition by this new type of Zn-containing DNA-binding domain.
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{{ABSTRACT_PUBMED_12682016}}
==About this Structure==
==About this Structure==
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[[Category: Protein/dna complex]]
[[Category: Protein/dna complex]]
[[Category: Transcription factor]]
[[Category: Transcription factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 01:23:51 2008''

Revision as of 22:24, 27 July 2008

Image:1odh.png

Template:STRUCTURE 1odh

STRUCTURE OF THE GCM DOMAIN BOUND TO DNA

Template:ABSTRACT PUBMED 12682016

About this Structure

1ODH is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structure of the GCM domain-DNA complex: a DNA-binding domain with a novel fold and mode of target site recognition., Cohen SX, Moulin M, Hashemolhosseini S, Kilian K, Wegner M, Muller CW, EMBO J. 2003 Apr 15;22(8):1835-45. PMID:12682016

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