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2ga0

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[[Image:2ga0.gif|left|200px]]
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{{STRUCTURE_2ga0| PDB=2ga0 | SCENE= }}
{{STRUCTURE_2ga0| PDB=2ga0 | SCENE= }}
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'''Variable Small Protein 1 of Borrelia turicatae (VspA or Vsp1)'''
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===Variable Small Protein 1 of Borrelia turicatae (VspA or Vsp1)===
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==Overview==
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Vsp surface lipoproteins are serotype-defining antigens of relapsing fever spirochetes that undergo multiphasic antigenic variation to allow bacterial persistence in spite of an immune response. Two isogenic serotypes of Borrelia turicatae strain Oz1 differ in their Vsp sequences and in disease manifestations in infected mice: Vsp1 is associated with the selection of a neurological niche, while Vsp2 is associated with blood and skin infection. We report here crystal structures of the Vsp1 dimer at 2.7 and 2.2 A. The structures confirm that relapsing fever Vsp proteins share a common helical fold with OspCs of Lyme disease-causing Borrelia. The fold features an inner stem formed by highly conserved N and C termini and an outer "dome" formed by the variable central residues. Both Vsp1 and OspC structures possess small water-filled cavities, or pockets, that are lined largely by variable residues and are thus highly variable in shape. These features appear to signify tolerance of the Vsp-OspC fold for imperfect packing of residues at its antigenic surface. Structural comparison of Vsp1 with a homology model for Vsp2 suggests that observed differences in disease manifestation may arise in part from distinct differences in electrostatic surface properties; additional predicted positively charged surface patches on Vsp2 compared to Vsp1 may be sufficient to explain the relative propensity of Vsp2 to bind to acidic glycosaminoglycans.
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The line below this paragraph, {{ABSTRACT_PUBMED_16740958}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16740958 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16740958}}
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
Crystal structure of neurotropism-associated variable surface protein 1 (Vsp1) of Borrelia turicatae., Lawson CL, Yung BH, Barbour AG, Zuckert WR, J Bacteriol. 2006 Jun;188(12):4522-30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16740958 16740958]
Crystal structure of neurotropism-associated variable surface protein 1 (Vsp1) of Borrelia turicatae., Lawson CL, Yung BH, Barbour AG, Zuckert WR, J Bacteriol. 2006 Jun;188(12):4522-30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16740958 16740958]
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Structural conservation of neurotropism-associated VspA within the variable Borrelia Vsp-OspC lipoprotein family., Zuckert WR, Kerentseva TA, Lawson CL, Barbour AG, J Biol Chem. 2001 Jan 5;276(1):457-63. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11018048 11018048]
[[Category: Borrelia turicatae]]
[[Category: Borrelia turicatae]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Zuckert, W R.]]
[[Category: Zuckert, W R.]]
[[Category: Helical bundle]]
[[Category: Helical bundle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:52:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:14:45 2008''

Revision as of 23:14, 27 July 2008

Image:2ga0.png

Template:STRUCTURE 2ga0

Variable Small Protein 1 of Borrelia turicatae (VspA or Vsp1)

Template:ABSTRACT PUBMED 16740958

About this Structure

2GA0 is a Single protein structure of sequence from Borrelia turicatae. Full crystallographic information is available from OCA.

Reference

Crystal structure of neurotropism-associated variable surface protein 1 (Vsp1) of Borrelia turicatae., Lawson CL, Yung BH, Barbour AG, Zuckert WR, J Bacteriol. 2006 Jun;188(12):4522-30. PMID:16740958

Structural conservation of neurotropism-associated VspA within the variable Borrelia Vsp-OspC lipoprotein family., Zuckert WR, Kerentseva TA, Lawson CL, Barbour AG, J Biol Chem. 2001 Jan 5;276(1):457-63. PMID:11018048

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