3fct

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[[Image:3fct.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_3fct| PDB=3fct | SCENE= }}
{{STRUCTURE_3fct| PDB=3fct | SCENE= }}
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'''MATURE METAL CHELATASE CATALYTIC ANTIBODY WITH HAPTEN'''
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===MATURE METAL CHELATASE CATALYTIC ANTIBODY WITH HAPTEN===
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==Overview==
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A classic hypothesis for enzyme catalysis is the induction of strain in the substrate. This notion was first expressed by Haldane with the lock and key analogy-"the key does not fit the lock perfectly but exercises a certain strain on it" (1). This mechanism has often been invoked to explain the catalytic efficiency of enzymes but has been difficult to establish conclusively (2-7). Here we describe X-ray crystallographic and mutational studies of an antibody metal chelatase which strongly support the notion that this antibody catalyzes metal ion insertion into the porphyrin ring by inducing strain. Analysis of the germline precursor suggests that this strain mechanism arose during the process of affinity maturation in response to a conformationally distorted N-alkylmesoporphyrin.
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The line below this paragraph, {{ABSTRACT_PUBMED_9772166}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9772166 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9772166}}
==About this Structure==
==About this Structure==
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[[Category: Fab fragment]]
[[Category: Fab fragment]]
[[Category: Metal chelatase]]
[[Category: Metal chelatase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:01:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:02:14 2008''

Revision as of 00:02, 28 July 2008

Image:3fct.png

Template:STRUCTURE 3fct

MATURE METAL CHELATASE CATALYTIC ANTIBODY WITH HAPTEN

Template:ABSTRACT PUBMED 9772166

About this Structure

Full crystallographic information is available from OCA.

Reference

Structural and kinetic evidence for strain in biological catalysis., Romesberg FE, Santarsiero BD, Spiller B, Yin J, Barnes D, Schultz PG, Stevens RC, Biochemistry. 1998 Oct 13;37(41):14404-9. PMID:9772166

Page seeded by OCA on Mon Jul 28 03:02:14 2008

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