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1wqd

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[[Image:1wqd.gif|left|200px]]
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{{STRUCTURE_1wqd| PDB=1wqd | SCENE= }}
{{STRUCTURE_1wqd| PDB=1wqd | SCENE= }}
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'''An unusual fold for potassium channel blockers: NMR structure of three toxins from the scorpion Opisthacanthus madagascariensis'''
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===An unusual fold for potassium channel blockers: NMR structure of three toxins from the scorpion Opisthacanthus madagascariensis===
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==Overview==
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The Om-toxins are short peptides (23-27 amino acids) purified from the venom of the scorpion Opisthacanthus madagascariensis. Their pharmacological targets are thought to be potassium channels. Like Csalpha/beta (cystine-stabilized alpha/beta) toxins, the Om-toxins alter the electrophysiological properties of these channels; however, they do not share any sequence similarity with other scorpion toxins. We herein demonstrate by electrophysiological experiments that Om-toxins decrease the amplitude of the K+ current of the rat channels Kv1.1 and Kv1.2, as well as human Kv1.3. We also determine the solution structure of three of the toxins by use of two-dimensional proton NMR techniques followed by distance geometry and molecular dynamics. The structures of these three peptides display an uncommon fold for ion-channel blockers, Csalpha/alpha (cystine-stabilized alpha-helix-loop-helix), i.e. two alpha-helices connected by a loop and stabilized by two disulphide bridges. We compare the structures obtained and the dipole moments resulting from the electrostatic anisotropy of these peptides with those of the only other toxin known to share the same fold, namely kappa-hefutoxin1.
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(as it appears on PubMed at http://www.pubmed.gov), where 15631621 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15631621}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WQD OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WQD OCA].
==Reference==
==Reference==
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[[Category: Tytgat, J.]]
[[Category: Tytgat, J.]]
[[Category: Toxin]]
[[Category: Toxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:00:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:20:51 2008''

Revision as of 00:20, 28 July 2008

Image:1wqd.png

Template:STRUCTURE 1wqd

An unusual fold for potassium channel blockers: NMR structure of three toxins from the scorpion Opisthacanthus madagascariensis

Template:ABSTRACT PUBMED 15631621

About this Structure

Full experimental information is available from OCA.

Reference

An unusual fold for potassium channel blockers: NMR structure of three toxins from the scorpion Opisthacanthus madagascariensis., Chagot B, Pimentel C, Dai L, Pil J, Tytgat J, Nakajima T, Corzo G, Darbon H, Ferrat G, Biochem J. 2005 May 15;388(Pt 1):263-71. PMID:15631621

Page seeded by OCA on Mon Jul 28 03:20:51 2008

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