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2fek

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[[Image:2fek.gif|left|200px]]
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{{STRUCTURE_2fek| PDB=2fek | SCENE= }}
{{STRUCTURE_2fek| PDB=2fek | SCENE= }}
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'''Structure of a protein tyrosine phosphatase'''
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===Structure of a protein tyrosine phosphatase===
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==Overview==
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Low molecular weight protein-tyrosine phosphatases (LMW-PTPs) are small enzymes that ubiquitously exist in various organisms and play important roles in many biological processes. In Escherichia coli, the LMW-PTP Wzb dephosphorylates the autokinase Wzc, and the Wzc/Wzb pair regulates colanic acid production. However, the substrate recognition mechanism of Wzb is still poorly understood thus far. To elucidate the molecular basis of the catalytic mechanism, we have determined the solution structure of Wzb at high resolution by NMR spectroscopy. The Wzb structure highly resembles that of the typical LMW-PTP fold, suggesting that Wzb may adopt a similar catalytic mechanism with other LMW-PTPs. Nevertheless, in comparison with eukaryotic LMW-PTPs, the absence of an aromatic amino acid at the bottom of the active site significantly alters the molecular surface and implicates Wzb may adopt a novel substrate recognition mechanism. Furthermore, a structure-based multiple sequence alignment suggests that a class of the prokaryotic LMW-PTPs may share a similar substrate recognition mechanism with Wzb. The current studies provide the structural basis for rational drug design against the pathogenic bacteria.
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(as it appears on PubMed at http://www.pubmed.gov), where 16651264 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16651264}}
==About this Structure==
==About this Structure==
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2FEK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FEK OCA].
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2FEK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FEK OCA].
==Reference==
==Reference==
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[[Category: Low molecular weight protein tyrosine phosphatase]]
[[Category: Low molecular weight protein tyrosine phosphatase]]
[[Category: Phosphate binding]]
[[Category: Phosphate binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:48:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:33:57 2008''

Revision as of 00:33, 28 July 2008

Image:2fek.png

Template:STRUCTURE 2fek

Structure of a protein tyrosine phosphatase

Template:ABSTRACT PUBMED 16651264

About this Structure

2FEK is a Single protein structure of sequence from Escherichia coli. Full experimental information is available from OCA.

Reference

The solution structure of Escherichia coli Wzb reveals a novel substrate recognition mechanism of prokaryotic low molecular weight protein-tyrosine phosphatases., Lescop E, Hu Y, Xu H, Hu W, Chen J, Xia B, Jin C, J Biol Chem. 2006 Jul 14;281(28):19570-7. Epub 2006 May 1. PMID:16651264

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