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1zj6

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[[Image:1zj6.gif|left|200px]]
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{{STRUCTURE_1zj6| PDB=1zj6 | SCENE= }}
{{STRUCTURE_1zj6| PDB=1zj6 | SCENE= }}
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'''Crystal structure of human ARL5'''
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===Crystal structure of human ARL5===
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==Overview==
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ARL5 is a member of ARLs, which is widespread in high eukaryotes and homologous between species. But no structure or biological function of this member is reported. We expressed, purified, and resolved the structure of human ARL5 with bound GDP3'P at 2.0 A resolution. A comparison with the known structures of ARFs shows that besides the typical features of ARFs, human ARL5 has specific features of its own. Bacterially expressed human ARL5 contains bound GDP3'P which is seldom seen in other structures. The hydrophobic tail of the introduced detergent Triton X-305 binds at the possible myristoylation site of Gly2, simulating the myristoylated state of N-terminal amphipathic helix in vivo. The structural features of the nucleotide binding motifs and the switch regions prove that ARL5 will undergo the typical GDP/GTP structural cycle as other members of ARLs, which is the basis of their biological functions.
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(as it appears on PubMed at http://www.pubmed.gov), where 15896705 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15896705}}
==About this Structure==
==About this Structure==
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[[Category: Arl]]
[[Category: Arl]]
[[Category: Gtp-binding]]
[[Category: Gtp-binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:41:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:36:09 2008''

Revision as of 00:36, 28 July 2008

Image:1zj6.png

Template:STRUCTURE 1zj6

Crystal structure of human ARL5

Template:ABSTRACT PUBMED 15896705

About this Structure

1ZJ6 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

2.0 A crystal structure of human ARL5-GDP3'P, a novel member of the small GTP-binding proteins., Wang ZX, Shi L, Liu JF, An XM, Chang WR, Liang DC, Biochem Biophys Res Commun. 2005 Jul 8;332(3):640-5. PMID:15896705

Page seeded by OCA on Mon Jul 28 03:36:09 2008

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