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2cs7

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[[Image:2cs7.gif|left|200px]]
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{{STRUCTURE_2cs7| PDB=2cs7 | SCENE= }}
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'''1.2 A Crystal structure of the S. pneumoniae PhtA histidine triad domain a novel zinc binding fold'''
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===1.2 A Crystal structure of the S. pneumoniae PhtA histidine triad domain a novel zinc binding fold===
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==Overview==
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The recently described pneumococcal histidine triad protein family has been shown to be highly conserved within the pneumococcus. As part of our structural genomics effort on proteins from Streptococcus pneumoniae, we have expressed, crystallised and solved the structure of PhtA-166-220 at 1.2 Angstroms using remote SAD with zinc. The structure of PhtA-166-220 shows no similarity to any protein structure. The overall fold contains 3beta-strands and a single short alpha-helix. The structure appears to contain a novel zinc binding motif. The remaining 4 histidine triad repeats from PhtA have been modelled based on the crystal structure of the PhtA histidine triad repeat 2. From this modelling work, we speculate that only three of the five histidine triad repeats contain the residues in the correct geometry to allow the binding of a zinc ion.
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(as it appears on PubMed at http://www.pubmed.gov), where 16194532 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16194532}}
==About this Structure==
==About this Structure==
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[[Category: Pneumococcal histidine triad protein]]
[[Category: Pneumococcal histidine triad protein]]
[[Category: S pneumoniae]]
[[Category: S pneumoniae]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 22:55:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:41:42 2008''

Revision as of 00:41, 28 July 2008

Image:2cs7.png

Template:STRUCTURE 2cs7

1.2 A Crystal structure of the S. pneumoniae PhtA histidine triad domain a novel zinc binding fold

Template:ABSTRACT PUBMED 16194532

About this Structure

2CS7 is a Single protein structure of sequence from Streptococcus pneumoniae. Full crystallographic information is available from OCA.

Reference

1.2 Angstroms crystal structure of the S. pneumoniae PhtA histidine triad domain a novel zinc binding fold., Riboldi-Tunnicliffe A, Isaacs NW, Mitchell TJ, FEBS Lett. 2005 Oct 10;579(24):5353-60. PMID:16194532

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