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2aqy

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[[Image:2aqy.gif|left|200px]]
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{{Seed}}
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[[Image:2aqy.png|left|200px]]
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{{STRUCTURE_2aqy| PDB=2aqy | SCENE= }}
{{STRUCTURE_2aqy| PDB=2aqy | SCENE= }}
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'''(3+1) assembly of three human telomeric DNA repeats into an asymmetrical dimeric G-quadruplex'''
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===(3+1) assembly of three human telomeric DNA repeats into an asymmetrical dimeric G-quadruplex===
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==Overview==
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We present an NMR study on the structure of a DNA fragment of the human telomere containing three guanine-tracts, d(GGGTTAGGGTTAGGGT). This sequence forms in Na(+) solution a unique asymmetric dimeric quadruplex, in which the G-tetrad core involves all three G-tracts of one strand and only the last 3'-end G-tract of the other strand. We show that a three-repeat human telomeric sequence can also associate with a single-repeat human telomeric sequence into a structure with the same topology that we name (3 + 1) quadruplex assembly. In this G-quadruplex assembly, there are one syn.syn.syn.anti and two anti.anti.anti.syn G-tetrads, two edgewise loops, three G-tracts oriented in one direction and the fourth oriented in the opposite direction. We discuss the possible implications of the new folding topology for understanding the structure of telomeric DNA, including t-loop formation, and for targeting G-quadruplexes in the telomeres.
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The line below this paragraph, {{ABSTRACT_PUBMED_16332077}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16332077 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16332077}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AQY OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AQY OCA].
==Reference==
==Reference==
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[[Category: Asymmetric dimeric g-quadruplex]]
[[Category: Asymmetric dimeric g-quadruplex]]
[[Category: Telomeric dna.]]
[[Category: Telomeric dna.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:21:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:41:42 2008''

Revision as of 00:41, 28 July 2008

Image:2aqy.png

Template:STRUCTURE 2aqy

(3+1) assembly of three human telomeric DNA repeats into an asymmetrical dimeric G-quadruplex

Template:ABSTRACT PUBMED 16332077

About this Structure

Full experimental information is available from OCA.

Reference

(3 + 1) Assembly of three human telomeric repeats into an asymmetric dimeric G-quadruplex., Zhang N, Phan AT, Patel DJ, J Am Chem Soc. 2005 Dec 14;127(49):17277-85. PMID:16332077

Page seeded by OCA on Mon Jul 28 03:41:42 2008

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